DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and dmsr-11

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_504725.2	Gene:	dmsr-11 / 191158	WormBaseID:	WBGene00022605	Length:	355	Species:	Caenorhabditis elegans

Alignment Length:	338	Identity:	61/338 - (18%)
Similarity:	129/338 - (38%)	Gaps:	88/338 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 VAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNL---HAC 112
            :.|.:...|:|::|:..|:.......|..::.:|:.|     ||...|.|:.:.| ||.   ::.
Worm    49 IVIFAFFANILILILLTRKEMRYSGVNVTMMLIAVCD-----LGCAIAGLSQLYL-RNFSDNYSS 107

  Fly   113 LFT--VSLLVVLCTISI------------FCLVAV------SVDRYWAILYPMAYSRNVRTRTAI 157
            ..|  ...:|..|.|:.            ||.|..      |.|.:.:..|.:        |.|:
Worm   108 YQTAYAQFIVYYCQIAFHAESLYLAVGMAFCRVITLSSASDSRDTWQSPKYAI--------RVAV 164

  Fly   158 FIISMCWVAGTIVGFL----------PLFGWHADVNHNQECLFVEVMDYNYLVFLYFATI---IT 209
            .:....:...:.|.||          .:|...:.::...:|||::..       ::|:..   |.
Worm   165 LLCFPVFAVSSFVLFLNSVKEVYADGSVFLDISPLSLANDCLFLKTS-------IFFSGSCFKIL 222

  Fly   210 PALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKR 274
            |::|| :.::.|..:.||..:|     .::.||...:....|:.
Worm   223 PSILM-SMFSIIILIRIKAGKQ-----RSNSLSHNQTDQDAQID--------------------- 260

  Fly   275 DVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYV--HPKLTLFCIILSHLNSAVNPVLYAYH 337
              ::|:.:.::|:.|:|...|....:.:.:...:.|:  :..|::|..||:..|:..:.::|:..
Worm   261 --RSTRFIQVVVVVFVITETPQGFFSVLGSISINDYINYYQHLSIFMNILAFFNTTTSFIIYSTL 323

  Fly   338 LKDFRAALKNLLL 350
            ...||.....|.:
Worm   324 SSKFRKLFAQLFV 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	39/203 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	56/313 (18%)
dmsr-11	NP_504725.2	7tmA_FMRFamide_R-like	40..331	CDD:320109	60/331 (18%)
		TM helix 1	42..66	CDD:320109	4/16 (25%)
		TM helix 2	75..96	CDD:320109	7/25 (28%)
		TM helix 3	115..137	CDD:320109	3/21 (14%)
		TM helix 4	161..177	CDD:320109	2/15 (13%)
		TM helix 5	209..232	CDD:320109	5/30 (17%)
		TM helix 6	260..285	CDD:320109	5/47 (11%)
		TM helix 7	299..324	CDD:320109	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910