DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and dmsr-10

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_504724.1	Gene:	dmsr-10 / 191157	WormBaseID:	WBGene00022604	Length:	299	Species:	Caenorhabditis elegans

Alignment Length:	331	Identity:	61/331 - (18%)
Similarity:	116/331 - (35%)	Gaps:	108/331 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DAKDSDSPSSELN---IPYTVFE----VLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMA 86
            ||||. ..|..:|   :.|..|.    ..|.|.:...|:|::||..|:.......|..::.:::.
Worm    21 DAKDL-VISQFINTVVLSYRPFHYFILACVVIFAFFANILILIVLSRKEMRYSGVNVTMMLISIC 84

  Fly    87 DLLVGALGIPFAILASMGLPR-----------------NLHACLFTVSLLVVLCTISIFCLVAVS 134
            ||:....|:....|.:..:..                 :.||....::|.:..|.:     ||:|
Worm    85 DLVCAIAGLIQLYLRNFSVTYTSYIKAYTQLTVDYFQISFHAASLYLALGMAFCRV-----VAMS 144

  Fly   135 V---DRY-WAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLP--LFGWH-ADVNHNQ------ 186
            .   .|| |       .|.....|.|:.   :|         :|  :||.| ..:||.:
Worm   145 SRTDSRYTW-------QSPKYSLRIALL---LC---------IPVFIFGSHNVLLNHVEIENGTI 190

  Fly   187 -----------ECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASD 240
                       .|||:::.  .:|..|:|.  |.|.:||:     :...:|
Worm   191 VLNISPLSLANSCLFLKLA--IFLNGLFFK--IVPCILMM-----VLSFVI-------------- 232

  Fly   241 LSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAF 305
            |:|..|..  :.:....|.|....:          |::::.:..:::.|:|...|...::.:...
Worm   233 LARMKSGK--KASNTNSGNHIDAQI----------VRSSRFIQAVIVVFVITEAPQGVLSLLGGL 285

  Fly   306 CPDCYV 311
            ..:.|:
Worm   286 SINDYI 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	41/208 (20%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	51/295 (17%)
dmsr-10	NP_504724.1	7tmA_FMRFamide_R-like	40..289	CDD:320109	53/307 (17%)
		TM helix 1	42..66	CDD:320109	6/23 (26%)
		TM helix 2	75..96	CDD:320109	4/20 (20%)
		TM helix 3	115..137	CDD:320109	3/21 (14%)
		TM helix 4	161..177	CDD:320109	6/27 (22%)
		TM helix 5	207..230	CDD:320109	7/31 (23%)
		TM helix 6	256..281	CDD:320109	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910