DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and dmsr-6

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_497004.1	Gene:	dmsr-6 / 190297	WormBaseID:	WBGene00013222	Length:	394	Species:	Caenorhabditis elegans

Alignment Length:	412	Identity:	72/412 - (17%)
Similarity:	135/412 - (32%)	Gaps:	133/412 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DAKDSDSPSSELNIPYTVFE-----------------VLVAIVSIIGNVLVIIVFRRERKLRRRT 76
            :..||....:..|:.|.|.|                 .::.::.:..|.:.|.|..|.|......
Worm     2 ECNDSRLFDTNNNLTYFVIEQFYRFRYLYSNVHPFLSFILCVLGLAANAIHITVLTRPRMRHSSV 66

  Fly    77 NYYIVSLAMADLLVGALG------IPFAILAS-------MGLPRNLHACLFTVSLLVVLCTISIF 128
            :..:|.:|::|:  |.:.      ..|..|:.       ..|....||     .|.:.|..|:::
Worm    67 HTVLVCIAISDM--GTMTSYLMYISRFEFLSDKEGYSYFWALFLKCHA-----MLSIALHAITLY 124

  Fly   129 CLVAVSVDRYWAI-LYPMAYSRNVRTRT-----AIFIISMCWVAGTIVGFLPLFGWHADVNHNQE 187
            .:|.::..|..|: |....:..:.|..|     |:|:..||         :|....| .::....
Worm   125 LVVLMAFIRLSAMKLTTSRWLDHTRALTSAIFIALFVFIMC---------VPTLLAH-QIDETTR 179

  Fly   188 CLFVEVMDYNYLVFLYFATII---------------------TPALLMLAFYTHIY--------- 222
            .:.:..|.|.|.|  .|:|::                     .|.||:|.|...:.
Worm   180 GVTMNGMYYKYSV--GFSTLMMQNGCSLMKGNLWLTGIFLKAIPCLLLLTFTIALINRLRENNEK 242

  Fly   223 -RVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIV 286
             :::||:.|                                        |:||....|..|.::|
Worm   243 RKILIKEER----------------------------------------AKKRGDFTTYMLLLMV 267

  Fly   287 LFFMICWIPLYTINCIKAFCPDCY---VHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNL 348
            ..|:...:|...:..:.|.....:   |:..|.....:||.:|..|..::|::....:|..|.:|
Worm   268 TVFLFTELPQGIMAILNALFTTQFHQMVYLNLADVLDLLSLINCYVAFLVYSFTSSRYRQTLFSL 332

  Fly   349 L----LKMMGVDIDQQAEAIHR 366
            |    :...|:...|.....|:
Worm   333 LPLTKISYSGISTRQGTLKSHQ 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	40/207 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	58/328 (18%)
dmsr-6	NP_497004.1	7tmA_FMRFamide_R-like	33..329	CDD:320109	60/354 (17%)
		TM helix 1	34..58	CDD:320109	3/23 (13%)
		TM helix 2	67..89	CDD:320109	4/23 (17%)
		TM helix 3	109..131	CDD:320109	6/26 (23%)
		TM helix 4	152..168	CDD:320109	5/24 (21%)
		TM helix 5	207..230	CDD:320109	5/22 (23%)
		TM helix 6	257..282	CDD:320109	5/24 (21%)
		TM helix 7	297..322	CDD:320109	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910