DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and dmsr-3

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_496818.1	Gene:	dmsr-3 / 190021	WormBaseID:	WBGene00012993	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	375	Identity:	73/375 - (19%)
Similarity:	143/375 - (38%)	Gaps:	132/375 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TVFE---------------VLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALG 94
            ||||               :|:.|...:|::|.|...   ..:...||.:::|::.:.|   ||.
Worm    11 TVFETFLLEYGRIIHPPMVLLLCISGALGHMLTITTL---SSMLNPTNMFLISMSCSQL---ALC 69

  Fly    95 IPF---------------AILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYP 144
            |.|               ....|..|...:|   |:|::.|::...::|.:||:|:.|::::...
Worm    70 INFLYSTFFKFMSDQLCQPFFFSYYLATTMH---FSVTVSVLVHMSAVFHVVALSLIRFFSLAQL 131

  Fly   145 MAYSRNV------RTRTAIF-----IISMCWVAGTIVGFLPLFGWH-----ADVNHNQECL---- 189
            .:.:.||      ::|.||.     :|.:|         :||   |     .:|:.|:.|.
Worm   132 SSVNSNVQWFTWQKSRVAIIMIYVSVIFLC---------IPL---HFTSQVTEVSENEGCAERYP 184

  Fly   190 --------------FVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASD 240
                          .:.:.:.|:.:| |....:.|::::.....    :|:.|:::|..
Worm   185 ALRNKVAYQLSYTQSIWLRNLNFWLF-YLVAKVVPSIILCIMTC----LILDQLKKIQV------ 238

  Fly   241 LSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIP------LYTI 299
            ||.|.|:.                     ...|:..:.|..:..|::.|:|..:|      |.|:
Worm   239 LSARFSSV---------------------ERDKQHSRTTNMILAIMILFIIVELPQGVLAVLSTV 282

  Fly   300 NCIKAFCPDCYVHPKLT-LFCIILSHLNSAVNPVLYAYHLKDFRAALKNL 348
            ..:|..    |....|| ||.::.|.:   :..:|.:.:.| .|:|.|.|
Worm   283 TSVKLI----YELGDLTELFTLLTSII---IFTLLCSMNGK-IRSAFKEL 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	40/216 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	61/331 (18%)
dmsr-3	NP_496818.1	7tm_GPCRs	23..321	CDD:391938	66/358 (18%)
		TM helix 1	24..48	CDD:341315	5/26 (19%)
		TM helix 2	54..78	CDD:341315	8/26 (31%)
		TM helix 3	99..129	CDD:341315	9/32 (28%)
		TM helix 4	144..164	CDD:341315	5/28 (18%)
		TM helix 5	203..228	CDD:341315	4/29 (14%)
		TM helix 6	250..280	CDD:341315	6/29 (21%)
		TM helix 7	291..314	CDD:341315	6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910