DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and srw-90

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_503486.1	Gene:	srw-90 / 189966	WormBaseID:	WBGene00005837	Length:	358	Species:	Caenorhabditis elegans

Alignment Length:	398	Identity:	80/398 - (20%)
Similarity:	134/398 - (33%)	Gaps:	133/398 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 HAATTSKDAKDSDSPSSELNIPYTVFEVLV-------AIVSIIGNVL---VIIVFRRERKLRRRT 76
            |.....:||..|:           .|::|.       .|.||||::|   .::|..|:..:...|
Worm     8 HHGFVEQDANSSN-----------FFQILAFQSLAVEFIFSIIGSILNFFHLVVLTRKSMMTSST 61

  Fly    77 NYYIVSLAMADL--LVGALGIPFAI------------LASMGLP---RNLH----ACLFTVSLLV 120
            |..::.:|:.||  ::..|...|.:            |:.|.|.   .::|    .|...:.:|:
Worm    62 NIIMIGIALCDLSCMLIILRNDFQLMDLRNKCNPPNTLSEMRLDWFLTSVHNASRRCSAWLGMLL 126

  Fly   121 VLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFG-----WHA 180
            .:....:...|....:||....|      .|:.....|.||.   |.||..:|.:..     |..
Worm   127 AVVRYRVISDVTNRKNRYSTQKY------GVKVTLTAFFISF---AFTISFYLHVENVQIGVWKP 182

  Fly   181 DVNHNQECLFVEV----MDYNYLVFL--------------YFATII----TPALLMLAFYTHIYR 223
            ||..:......|:    ..||.|..:              .||.:|    .|.|.:|..|.
Worm   183 DVQCSHSTQIEEIPVYAQQYNSLFLMNDYILGRIRMFIEAVFAKLIPCFTLPFLNVLLIYG---- 243

  Fly   224 VIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLF 288
                              .|:|:::.|::..      |...||    ..|:|     ..:|.::|
Worm   244 ------------------MRKSNSSTVEIAA------TNKNLR----NSKKD-----RTTIFIIF 275

  Fly   289 ----FMICWIP-----LYTINCIKAFCPDCYVHPKL----TLFCIILSHLNSAVNPVLYAYHLKD 340
                |.|...|     |||...:|.     ....||    .|.|..|..:|::::.|:.......
Worm   276 VATSFFISEFPLGIADLYTAIWLKE-----AQFRKLAQNTVLLCDSLFTVNASIHCVVCFSMSLQ 335

  Fly   341 FRAALKNL 348
            :|.|:.|:
Worm   336 YRKAVYNM 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	47/218 (22%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	67/339 (20%)
srw-90	NP_503486.1	7TM_GPCR_Srw	32..346	CDD:370978	74/363 (20%)
		TM helix 1	32..53	CDD:320109	7/20 (35%)
		TM helix 2	62..84	CDD:320109	5/21 (24%)
		TM helix 3	106..128	CDD:320109	3/21 (14%)
		TM helix 4	152..168	CDD:320109	6/18 (33%)
		TM helix 5	215..238	CDD:320109	5/22 (23%)
		TM helix 6	267..292	CDD:320109	6/29 (21%)
		TM helix 7	308..333	CDD:320109	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910