DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and frpr-19

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001370911.1	Gene:	frpr-19 / 189817	WormBaseID:	WBGene00021510	Length:	390	Species:	Caenorhabditis elegans

Alignment Length:	420	Identity:	90/420 - (21%)
Similarity:	158/420 - (37%)	Gaps:	106/420 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TDFSFEG---PLLPLHAATTSKDAK---------DSDSPSSELNI------PYTVFE-------- 48
            ||.:|.|   ||:.:.....|.|..         :.:...:.|||      .|:.:|
Worm     3 TDANFTGDPSPLVSVLGLIKSPDLMIGSTEVPLFEEEDMCTPLNISCACHTDYSSYEGLERVFLG 67

  Fly    49 ---VLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPR--- 107
               |.|.:..|:.||..:.:|..........|:|:..|:.:|.|     |.|:....:.|||
Worm    68 LVAVPVIMFGILANVTSMRIFTHRIMSGSSINWYLAVLSASDTL-----ILFSAFFVLSLPRFGE 127

  Fly   108 ------------NLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNV----RTRTA 156
                        ::..|::  .|::...|.|:|..|.|||.||..:.:|.   ::|    :.|..
Worm   128 YLTWWRANYISYSVTPCMY--GLMMTAQTCSVFMTVGVSVHRYIGVCHPY---KSVEWLPKKRVT 187

  Fly   157 IFIISMCWVAGTIVGFLPLFGW--HADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYT 219
            .|||.       ::.|..:|..  ..:|:.:..| :.|.:||      |..::...||.|...|.
Worm   188 TFIIG-------LLTFSVIFNTTRFFEVHISNVC-YRENIDY------YMPSLQPTALRMNDLYR 238

  Fly   220 HI-----YRVIIKQV--RQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGA-----AR 272
            .|     |.:::..|  ..::.:|          :.|:......|..|   |:...||     ::
Worm   239 QIFFGWAYTIVMYVVPFTLLIALN----------SMVLSAVRRSRRMH---MVSQCGAESEEFSK 290

  Fly   273 KRDVKATQN---LSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLY 334
            |.:.|..|.   |..|||.|:.|....:..|.::....:..::..|..|..:|..:|::.|..:|
Worm   291 KAERKERQTSIMLISIVLLFIACNTLAFVCNIMENMGTEGAIYQTLVTFNNLLVIINASCNICVY 355

  Fly   335 AYHLKDFRAALKNLLLKMMGVDIDQQAEAI 364
            ......:|..|:..|.    .|..:|.|.:
Worm   356 MLFSGKYRMLLRYYLF----CDWSRQGELL 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	43/188 (23%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	67/311 (22%)
frpr-19	NP_001370911.1	7tmA_FMRFamide_R-like	64..363	CDD:410630	71/335 (21%)
		TM helix 1	66..90	CDD:410630	6/23 (26%)
		TM helix 2	99..121	CDD:410630	7/26 (27%)
		TM helix 3	143..165	CDD:410630	7/23 (30%)
		TM helix 4	188..204	CDD:410630	5/22 (23%)
		TM helix 5	240..263	CDD:410630	4/32 (13%)
		TM helix 6	300..322	CDD:410630	6/21 (29%)
		TM helix 7	334..359	CDD:410630	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910