DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and dmsr-13

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_504730.1	Gene:	dmsr-13 / 188522	WormBaseID:	WBGene00020524	Length:	362	Species:	Caenorhabditis elegans

Alignment Length:	365	Identity:	66/365 - (18%)
Similarity:	135/365 - (36%)	Gaps:	81/365 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 YTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMG---- 104
            |.:...|| :.:...|::::.|...:..:|...|..::.:|:.|......|:....|.|..
Worm    43 YYILTFLV-VFAFFANIMIVKVLSHKEMIRSGVNVTMLLIAVCDFGCSIAGLLQLFLRSYSDNYT 106

  Fly   105 -------------LPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTA 156
                         |....||....:::.:..|.:....:...:.| .|       .|.|...|.|
Worm   107 SYPTAYGQIAVDYLAVAFHASSLYLAVGMAFCRVKSLNIANRNKD-LW-------QSPNYAVRVA 163

  Fly   157 IFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYL---VFLYFATI-------ITPA 211
            ..:.:..::..|.|.|:     :|..|..:|.:::::.|.:.|   :|:..:.:       |.|.
Worm   164 CALCAPVFLIATFVLFI-----NAVKNTEEEGIYLDISDLSLLSECLFMKASLMASGLCFKIAPC 223

  Fly   212 LLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRS--SAAVVQVTTPGRGGHTGTMLRVLGAARKR 274
            ||||.....:.|.|              |..::|  :||..|                .|...|.
Worm   224 LLMLVLSLFLLRRI--------------DEGKQSAQNAAANQ----------------KGKKDKI 258

  Fly   275 DVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVH--PKLTLFCIILSHLNSAVNPVLYAYH 337
            | ::::.:..:::.|:|...|....:.:..|....|::  ..|::|..||:..|:..:.::|:..
Worm   259 D-RSSRFIQFVLVVFLITESPQGVFSILGGFMILDYINYFQNLSIFMNILAFFNTTTSFIIYSSL 322

  Fly   338 LKDFRAALKNLLLKMMGVD---IDQQAEAIHRFSVASQHR 374
            ...||.....|.|....::   :.:....:|  |:|...|
Worm   323 SAKFRRIFAQLFLPSQVLEKIYLKRSTVVVH--SIAHSSR 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	34/194 (18%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	54/306 (18%)
dmsr-13	NP_504730.1	7tmA_FMRFamide_R-like	40..330	CDD:320109	60/331 (18%)
		TM helix 1	42..66	CDD:320109	5/23 (22%)
		TM helix 2	75..97	CDD:320109	4/21 (19%)
		TM helix 3	115..137	CDD:320109	3/21 (14%)
		TM helix 4	161..177	CDD:320109	3/15 (20%)
		TM helix 5	208..228	CDD:320109	5/19 (26%)
		TM helix 6	259..284	CDD:320109	4/25 (16%)
		TM helix 7	298..323	CDD:320109	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910