DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and dmsr-14

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001309648.1	Gene:	dmsr-14 / 188521	WormBaseID:	WBGene00020523	Length:	353	Species:	Caenorhabditis elegans

Alignment Length:	346	Identity:	69/346 - (19%)
Similarity:	129/346 - (37%)	Gaps:	86/346 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PYTVFEVLVAIV-SIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMG-- 104
            ||..:.:...|| |...|:|::||...:.......|..::.:|::|......|:....:.:..
Worm    40 PYHYYLLSSLIVFSFFANILIVIVLSHKEMRHSGINVIMMFIAVSDFGCAVTGLMQLFIRNYSDQ 104

  Fly   105 --LPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTR----------TAI 157
              |....:..||...|.||....|:|....:::.|..|    :.:|..::.:          |..
Worm   105 YMLFITAYLQLFVDYLAVVFHASSLFLAAGMALCRVMA----LNFSNRLKDKWQSPRYALRVTCA 165

  Fly   158 FIISMCWVAGTIVGFLPLFGWHADVNHNQEC----LFVEVMDYN----------YLVFLYFATII 208
            ..|::..|:..||          .||..::.    ::::..|::          .|||:.....:
Worm   166 VYITVLTVSTLIV----------PVNEVKKTDDGEVYIDTSDFSLAYGCLLMKIVLVFVGICFKL 220

  Fly   209 TPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARK 273
            .|..|||     |..:::.|         ..|..:|||       .|....|            |
Worm   221 IPCTLML-----ILSILLLQ---------KMDEGKRSS-------VPINRNH------------K 252

  Fly   274 RDV--KATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYV--HPKLTLFCIILSHLNSAVNPVLY 334
            :|.  :::|.:..|::.|:|..:|....:.|.......|:  :..||:|..:||..|:..:.::|
Worm   253 KDQLDRSSQLIQTILIVFLITEVPQGVFSIIGGIEVIDYLNYYQNLTIFMNVLSFFNTTTSFIIY 317

  Fly   335 AYHLKDFRAAL------KNLL 349
            :.....||...      ||||
Worm   318 SSLSAKFRRIFAQTFLPKNLL 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	37/196 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	57/307 (19%)
dmsr-14	NP_001309648.1	7tmA_FMRFamide_R-like	40..328	CDD:320109	65/334 (19%)
		TM helix 1	42..66	CDD:320109	7/23 (30%)
		TM helix 2	75..97	CDD:320109	4/21 (19%)
		TM helix 3	115..137	CDD:320109	7/21 (33%)
		TM helix 4	161..177	CDD:320109	3/15 (20%)
		TM helix 5	208..231	CDD:320109	8/27 (30%)
		TM helix 6	257..282	CDD:320109	5/24 (21%)
		TM helix 7	296..321	CDD:320109	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910