DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AdoR and npr-31

DIOPT Version :9

Sequence 1:NP_651772.1 Gene:AdoR / 43583 FlyBaseID:FBgn0039747 Length:774 Species:Drosophila melanogaster
Sequence 2:NP_495481.2 Gene:npr-31 / 188235 WormBaseID:WBGene00020319 Length:408 Species:Caenorhabditis elegans


Alignment Length:531 Identity:111/531 - (20%)
Similarity:182/531 - (34%) Gaps:184/531 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 PYTVFEVLVAIV--SIIGNVLVIIVFRRERKLRR---------RTNYYIVSLAMAD------LLV 90
            ||....:.:|.|  .:.||:.|:....|.||.:.         |...||..||:.|      |||
 Worm     4 PYFAGFLYIATVLTGLFGNIWVVCSVARSRKPKSLMSRSSPSDRLRAYISVLAVIDLTVLMALLV 68

  Fly    91 GALGIPFAILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTR- 154
            .||   :..|....|..|....:|.:...|.:.::::  |..:|::||..|..|  :...||.: 
 Worm    69 RAL---YHFLPHFMLDSNSCRAMFVLENSVKITSLTV--LSCISIERYITIRKP--FCSEVRRQF 126

  Fly   155 -------TAIFIISMCWVAGTIVGFLPLFGWHADVN------HNQECLFVEVMDYNYLVFLYFAT 206
                   .:||:       |.:||.:.:     .:|      ....|    |..|........|:
 Worm   127 VNATPIGASIFV-------GLVVGAIIV-----QINSVTVSSDGLNC----VRSYRGKAIPRVAS 175

  Fly   207 IITPALLMLAFYTHI---YRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVL 268
            .:| |:..|...|.|   |..|::.||:..|...|. :...|......|..|       ..:|.:
 Worm   176 YLT-AVAFLVDLTIISLNYSQIVRHVRRKFTKRRAR-VQANSRVRESLVNEP-------RYMREM 231

  Fly   269 GAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLT----LF----------- 318
            .||..|          :.:|.::||:|:    .:..|.||..:..:||    ||           
 Worm   232 TAAIVR----------VGVFHVVCWLPM----SLMQFIPDNTIQSELTAGIRLFSNFRDYSITRW 282

  Fly   319 ----CIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVASQHRLQSMD 379
                ...|:.:|:|.:.:.||...:|    |:||:                ||  |::.|.:|..
 Worm   283 LIFIATWLTSMNAAGDWIFYAVMNRD----LRNLI----------------RF--ATERRKRSTM 325

  Fly   380 SNMRSTQPRLYVGEYSPIWLRQQQEALKNSQLLPKCGVVSPCFNNINQTVAAVASVTTDLEREMW 444
            |:..|......        ||||               |.|       ::..:.|::        
 Worm   326 SHAASPSTNRS--------LRQQ---------------VPP-------SMKVLHSIS-------- 352

  Fly   445 NIVEASSGAELGETSYEFPSPAPGSQRSSERNSSSTVPPAPPAP----AKPSVPSASYDNHNYSF 505
              ..:|.|..:.:        |.|:.........|||...|.:|    ||.|:           .
 Worm   353 --YRSSIGGSMDD--------AAGASFLQSSPKESTVSQEPNSPYGVRAKISI-----------L 396

  Fly   506 SQDEDEDDDDL 516
            ::.|.:.|.|:
 Worm   397 TRKESDGDGDM 407

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdoRNP_651772.1 7tm_4 52..>220 CDD:304433 45/198 (23%)
7tm_1 58..334 CDD:278431 72/326 (22%)
npr-31NP_495481.2 7tm_classA_rhodopsin-like 9..306 CDD:381740 76/342 (22%)
TM helix 1 9..31 CDD:381740 5/21 (24%)
TM helix 2 40..70 CDD:381740 9/29 (31%)
TM helix 3 86..108 CDD:381740 3/23 (13%)
TM helix 4 131..145 CDD:381740 5/20 (25%)
TM helix 5 171..194 CDD:381740 6/23 (26%)
TM helix 6 225..254 CDD:381740 9/49 (18%)
TM helix 7 281..306 CDD:381740 5/24 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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