DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and ntr-1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001360454.1	Gene:	ntr-1 / 188227	WormBaseID:	WBGene00011582	Length:	402	Species:	Caenorhabditis elegans

Alignment Length:	335	Identity:	82/335 - (24%)
Similarity:	147/335 - (43%)	Gaps:	36/335 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVI-IVFRRERKLRRR----TNYYIVSLAMADL 88
            |::..|.||.|:.:   :..:::.:|::.||.|:| ::::....|||:    ....::.:..||:
Worm    43 DSQPMDPPSLEIMM---LHHLMIILVTLFGNTLLIYVIYKNNAVLRRKRVTPVQMLMLHMCAADI 104

  Fly    89 LVG--ALGIPFAILASMGL---PRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYS 148
            |..  ::|...||.|::..   |..|  |..|..|.|:....|.|.|||:|.|||.||..|:|..
Worm   105 LFALISVGPTMAITATVPFFYGPNLL--CKLTKFLQVIPMYASSFLLVAISADRYQAICRPLASM 167

  Fly   149 R-NVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECL--FVEVMDYNYLVFLYFATIITP 210
            : ::..|.|:: ..:.|.|..:.....|:.:.   ..|.:|.  :...:.|...|.|:.:.:
Worm   168 KSSIYNRPALY-SGIAWTAAILFSTPQLYLFE---KRNGDCSENYTTALQYQLYVCLFNSVV--- 225

  Fly   211 ALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGG----HTGTMLRVLGAA 271
            .||..|....:|..:.|.|.:..:.  :|.|............|...||    |.|..::.:...
Worm   226 WLLPSAIAGWLYLCVCKAVWKSTSF--SSSLRNNMKKMEHMKLTEKNGGMQAHHKGATMQCVELD 288

  Fly   272 RKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAY 336
            |:|.......|:|:...|:: |.|....:.|.|..|.. ::.....:.:...:|||.:||.|: :
Worm   289 RRRVQTVKLTLTIVAANFVL-WAPFCITSVIDAVWPTA-INSTFATYIMFFGNLNSCMNPWLW-F 350

  Fly   337 HLKDFRAALK 346
            |..  |..||
Worm   351 HFN--RKQLK 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	47/180 (26%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	71/292 (24%)
ntr-1	NP_001360454.1	7tmA_Vasopressin_Oxytocin	53..361	CDD:320324	78/325 (24%)
		TM helix 1	55..79	CDD:320324	5/26 (19%)
		TM helix 2	93..116	CDD:320324	4/22 (18%)
		TM helix 3	132..154	CDD:320324	8/21 (38%)
		TM helix 4	177..193	CDD:320324	2/16 (13%)
		TM helix 5	215..238	CDD:320324	5/25 (20%)
		TM helix 6	292..317	CDD:320324	5/25 (20%)
		TM helix 7	328..353	CDD:320324	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910