DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and srw-133

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_504144.2	Gene:	srw-133 / 188102	WormBaseID:	WBGene00005880	Length:	372	Species:	Caenorhabditis elegans

Alignment Length:	380	Identity:	82/380 - (21%)
Similarity:	144/380 - (37%)	Gaps:	107/380 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMAD-----LLVGALGIPFAILASMG 104
            :.:|.:.:.|..:.||:.|:|..|:.......|..:.::|:.|     |..|.|.:  .|::|..
Worm    38 SAYEYIASCVCFLINVVHILVLTRKSMRTSSINVIMTAVAIFDICSYLLNFGTLAV--RIISSYS 100

  Fly   105 LPRN--------LHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMA--YSRNVRTRTA--- 156
            ...|        |:.|||.::.....|  |.:.|.:|:|.|...|..||:  |::...:.||
Worm   101 KCFNESSYQMIFLNNCLFFINEYARRC--STWLLFSVAVIRTLVIRNPMSPKYAKLSNSSTALRV 163

  Fly   157 IFIISMCWVAGTIVGFLPLFGWHADVNHN--------QECLFVEVMDYNYLV---------FLY- 203
            ||.:|:..:         :|..:..:.:.        .||....|:.|.::|         ||.
Worm   164 IFGVSIICI---------IFSINTALENEIEIIDRKPSECNSKGVISYGHVVSKLFWQNDEFLLK 219

  Fly   204 ---FATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTML 265
               |.|.|...::....:..|..::|.::|:|       |:.|:||.:
Worm   220 ISTFTTAIVSHIIPCILFPIITIILINELRRI-------DVKRKSSTS----------------- 260

  Fly   266 RVLGAARKRDVKATQNLSIIVLF----FMICWIPLYTINCIKAFCPDCYVHPKLT--------LF 318
                   ....|.:||.:.:|.:    |:|...||.....:..|..|.   |.|.        ||
Worm   261 -------SNKAKDSQNRTKLVFYNTILFLIAEFPLGFSMAVTWFFVDV---PGLQLIFSYSQYLF 315

  Fly   319 CIILSHLNSAVNPVLYAYHLKDFRAALKNL-----LLKMMGVDI---DQQAEAIH 365
            .::|: :|::.:.|:.......:|...|.|     |||...|.|   .|.|.:.|
Worm   316 SVVLT-INTSSHFVICMLMSSQYRNNAKILIFNVELLKNKKVSISSLSQTASSTH 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	45/206 (22%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	69/326 (21%)
srw-133	NP_504144.2	TM helix 1	37..61	CDD:320109	6/22 (27%)
		7TM_GPCR_Srw	40..346	CDD:370978	74/353 (21%)
		TM helix 2	70..92	CDD:320109	5/21 (24%)
		TM helix 3	115..137	CDD:320109	7/23 (30%)
		TM helix 4	162..178	CDD:320109	4/24 (17%)
		TM helix 5	219..242	CDD:320109	4/22 (18%)
		TM helix 6	268..293	CDD:320109	7/24 (29%)
		TM helix 7	309..334	CDD:320109	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910