DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and srw-2

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_503766.3	Gene:	srw-2 / 188012	WormBaseID:	WBGene00005749	Length:	373	Species:	Caenorhabditis elegans

Alignment Length:	359	Identity:	60/359 - (16%)
Similarity:	113/359 - (31%)	Gaps:	107/359 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VLVAIVSIIGNVLVIIVFR----RERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNL 109
            :::.|:.||..:|..|.|.    || .|..:..|  |::...|.|:...|:|...:...|
Worm    77 IVICILDIISEILSFISFSPFWIRE-TLEGQECY--VTVTYRDALIDQYGVPVLDMTQRG----- 133

  Fly   110 HACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFII------SMCWVAGT 168
                            |.:..:.:::.|..||.|||:.:........:|::      .:|.:..|
Worm   134 ----------------SSWLNLFMALLRVLAITYPMSSAIEKPVIVPVFVLISLIFNGICSICVT 182

  Fly   169 IVGFLPLFGWHADVNH---------NQECLFVEVMDY------------NYLVFLYFATIITPAL 212
                     |:.:|..         .|..|......|            :.|||:|......|:|
Worm   183 ---------WNFEVTQQYMDFSCDGTQNLLPANASRYIRTVPVGKKELHSTLVFIYGIIKALPSL 238

  Fly   213 LMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVK 277
                            |..|:.:....:|.|.|......:.:.|:|
Worm   239 ----------------VEPILAVILIMELKRASQRRKTMLKSDGKG------------------- 268

  Fly   278 ATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKL----TLFCIILSHLNSAVNPVLYAYHL 338
              :|.:.::||..|....|...|....|....:....|    :...::.:.:....|...:.:..
Worm   269 --ENTTKLILFMTISSFLLEVPNGFSHFAFGFFTTSPLIKTASYLIMVFAEIFPVTNSSTHLFVC 331

  Fly   339 KDFRAALKNLLLKMMGVDIDQ--QAEAIHRFSVA 370
            .......:...:.|||:...:  :.|.:.:.|||
Worm   332 FFMSTLYRETAISMMGISKQKITKVEEVRQTSVA 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	37/198 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	50/310 (16%)
srw-2	NP_503766.3	7TM_GPCR_Srw	42..348	CDD:370978	55/340 (16%)
		TM helix 1	42..65	CDD:341315
		TM helix 2	72..97	CDD:341315	6/19 (32%)
		TM helix 3	120..150	CDD:341315	6/50 (12%)
		TM helix 4	158..176	CDD:341315	1/17 (6%)
		TM helix 5	211..246	CDD:341315	8/50 (16%)
		TM helix 6	266..296	CDD:341315	9/50 (18%)
		TM helix 7	309..335	CDD:341315	1/25 (4%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910