DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and srw-136

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_503821.2	Gene:	srw-136 / 187331	WormBaseID:	WBGene00005883	Length:	378	Species:	Caenorhabditis elegans

Alignment Length:	331	Identity:	55/331 - (16%)
Similarity:	122/331 - (36%)	Gaps:	76/331 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMG 104
            :::..::.|..::::.|:.|:|..::..::.......|..:.::|:.|:|.      |.......
Worm    32 VSLTISIIEPYLSVICILINILHFVILTKKSMRSSSINLIMAAVAIFDILT------FLFQFKQI 90

  Fly   105 LPRNLHA---CLFTVSLLVVL--------------CTISIFCLVAVSVDRYWAILYPM--AYSRN 150
            :...:||   ||...|..:.|              |:..:|  ::::..|...:..||  .|.:.
Worm    91 ISHFIHASSPCLGRFSYWITLIDKSGFVIKDFSRRCSTWLF--LSIAFIRTLIVRNPMNLKYKQL 153

  Fly   151 VRTRTAIFIISMCWVAGTIVGFLPLFGWH-ADVNHNQEC-------LFVEVMDYNYLVFL-YFAT 206
            ....||.:.|...::.......:.:|..: .::....||       .|::|.:|    |: ..|.
Worm   154 SNQPTAFYTIFGVFLLSLPSSAIQIFENNIIEIWQKTECQPQGELTYFIDVAEY----FMRENAV 214

  Fly   207 IITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAA 271
            ::..|::|.|..::|....:   ..|||.....:|.:...:. .::|......|..:.
Worm   215 LVKVAIIMDALISNIIPCFL---FPIVTFLLVKELFKTEKSR-KKLTKNSSSNHNDSQ------- 268

  Fly   272 RKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLF-------CIILSHLNSAV 329
                 |.|:.:....:.|.:...||             .|:..:|.|       .:|:||..:..
Worm   269 -----KTTKLVFYNTIIFFVAEFPL-------------GVNTSITWFFMGAPGIMMIMSHFGNIF 315

  Fly   330 NPVLYA 335
            :.:|.|
Worm   316 SLLLSA 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	34/195 (17%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	51/310 (16%)
srw-136	NP_503821.2	TM helix 1	36..60	CDD:320109	4/23 (17%)
		7TM_GPCR_Srw	39..348	CDD:370978	55/324 (17%)
		TM helix 2	69..91	CDD:320109	5/27 (19%)
		TM helix 3	114..136	CDD:320109	2/23 (9%)
		TM helix 4	161..177	CDD:320109	1/15 (7%)
		TM helix 5	217..240	CDD:320109	6/25 (24%)
		TM helix 6	268..293	CDD:320109	6/49 (12%)
		TM helix 7	309..334	CDD:320109	4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910