DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and srw-115

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_503815.2	Gene:	srw-115 / 187325	WormBaseID:	WBGene00005862	Length:	367	Species:	Caenorhabditis elegans

Alignment Length:	448	Identity:	81/448 - (18%)
Similarity:	139/448 - (31%)	Gaps:	189/448 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLPLHAATTSKDAKDSDSPSSELNIPYT--VFEVL--VAIVSIIGNVLVIIVFRRERKLRRRTNY 78
            ||.|:.|...|....|.....:..||::  |...|  |:|.||:.|::...:..|:.......|.
Worm     8 LLSLYYAGFEKSTAKSLCEFEKKFIPFSSNVLSYLPDVSIASILINLIHFFILTRKPMRTSSINI 72

  Fly    79 YIVSLAMADLLVGALGIPFAILASMGLPRNLHACLF-------------TVSLLVVLCTISIFCL 130
            .:.::|:.|:|        |.|..:.|..:.::.:|             |..||.|:...|..|.
Worm    73 LMAAIALFDIL--------ASLQQIELLLDRYSYIFFDCYPTYTYGLELTKVLLDVVRDYSRRCS 129

  Fly   131 VAVSVDRYWAILYPMAYSRNVRTR---------------TAIFIISMCWVA--GTIVGFLPLFGW 178
            .       |.|:: :|:.|.:..|               :||.|..:|..:  .:::.||
Worm   130 T-------WLIVF-IAFIRTLIVRNPMSTKFEALCQPKASAIIIAGICATSFPVSVLKFL----- 181

  Fly   179 HADVNHNQECLFVEV---------------------------MDYNYLVFLYFATIITPALLMLA 216
                    |..|:|:                           ..|.|| |..|.:.|.|.:|:
Worm   182 --------EYQFIEIEGLESCAKGPHHIFAVSDLFTANDGFLAKYFYL-FNSFVSDIVPCILL-- 235

  Fly   217 FYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRD--VKAT 279
                          .|||:....||.|                          ||:||.  :..:
Worm   236 --------------PIVTLLLVMDLWR--------------------------AAKKRTNLISVS 260

  Fly   280 QN--------LSIIVLFFMI----------CWI-------------------PLYTINCIKAFCP 307
            :|        ..:.::||::          .|:                   .|.|:|.    |.
Worm   261 KNHNSRTGLVFCVTIMFFIVEFPYGLSMGFVWMYNDVLGLQHMMSRFAFMFAMLITLNT----CT 321

  Fly   308 DCYVHPKLTLFCIIL-SHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAI 364
            ..:|       |:|: ||..|....|....::..     ||.:.....|....|::.:
Worm   322 HLFV-------CLIISSHYRSTAIYVFSCGYINS-----KNTIASRTQVTSSSQSKTL 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	41/224 (18%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	63/372 (17%)
srw-115	NP_503815.2	TM helix 1	41..62	CDD:320109	6/20 (30%)
		7TM_GPCR_Srw	45..344	CDD:370978	67/381 (18%)
		TM helix 2	71..93	CDD:320109	7/29 (24%)
		TM helix 3	116..138	CDD:320109	7/29 (24%)
		TM helix 4	163..179	CDD:320109	3/15 (20%)
		TM helix 5	217..240	CDD:320109	10/39 (26%)
		TM helix 6	267..289	CDD:320109	2/21 (10%)
		TM helix 7	305..330	CDD:320109	7/35 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910