DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and srw-121

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_503814.2	Gene:	srw-121 / 187324	WormBaseID:	WBGene00005868	Length:	362	Species:	Caenorhabditis elegans

Alignment Length:	352	Identity:	55/352 - (15%)
Similarity:	120/352 - (34%)	Gaps:	117/352 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 VAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLL-----VGALGIPFAILASMGLPRNLH 110
            ::|.|:|.|:|...:..|:.......|..:.::|:.|:.     :..:...:..:....||::.:
Worm    45 ISISSVIINLLHFFILTRKPMRTSSINNLMAAVALFDIFTCFQQIEIIFEKYKYIFFSCLPKDTY 109

  Fly   111 ACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTR---------------TAIFII 160
            ..:...:||:|:...:..|..       |.|:: :|..|.:..|               .||.|.
Worm   110 GLVLARTLLIVVQDYARKCST-------WLIIF-IAMIRTLLVRNPLSNQFESLGKPKAAAIVIA 166

  Fly   161 SMC----------WVAGTIVGFLPLFGWHADVNHNQEC-------------LFVE----VMDYNY 198
            .:|          ::..|::..:|          .|.|             ||::    :..|..
Worm   167 IVCISSLPVSMFRFLENTLMESIP----------RQSCAPNRTYYEYVGSELFMDNEGSIAKYFN 221

  Fly   199 LVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGT 263
            |:....:.||....|.:.....:|.|:....::...::..:|.|.|              |.||.
Worm   222 LLNSLVSDIIPCISLPIVTCLLVYAVLKSNKKRAKLISSYTDKSSR--------------GKTGL 272

  Fly   264 MLRVLGAARKRDVKATQNLSIIVLFFMI----------CWIPLYTINCIKAFCPDCY--VHPKLT 316
            :                 ..:.::||::          .||.|        ..|..|  ::...:
Worm   273 V-----------------FCVAIMFFIVEFPYGLSIGTAWIFL--------LAPGVYNILNQLAS 312

  Fly   317 LFCIILSHLNSAVNPVLYAYHLKDFRA 343
            :|.:::: |||..:.::.......:|:
Worm   313 IFSMLIT-LNSCTHLIICLIMSSQYRS 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	35/214 (16%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	51/334 (15%)
srw-121	NP_503814.2	7TM_GPCR_Srw	41..347	CDD:370978	55/352 (16%)
		TM helix 2	71..93	CDD:320109	3/21 (14%)
		TM helix 3	116..138	CDD:320109	6/29 (21%)
		TM helix 4	163..179	CDD:320109	3/15 (20%)
		TM helix 5	218..241	CDD:320109	5/22 (23%)
		TM helix 6	270..292	CDD:320109	4/38 (11%)
		TM helix 7	308..333	CDD:320109	4/25 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910