DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and srw-31

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_507435.2	Gene:	srw-31 / 186943	WormBaseID:	WBGene00005778	Length:	367	Species:	Caenorhabditis elegans

Alignment Length:	339	Identity:	65/339 - (19%)
Similarity:	121/339 - (35%)	Gaps:	96/339 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 IVSIIGNVLVII---VFRRERKLRRRTNYYIVSLAMADLL----VGALGIPFAIL-------ASM 103
            :..|:|.||.:|   :..|:.......|.:::.:|.|::.    :..:.|||..|       :..
Worm    40 VALIVGTVLGVIHLTILTRKCMRALSINVFLIGIAAAEIFRAICILIIFIPFFDLRYLSDEVSDC 104

  Fly   104 GLPRNLHACL---FTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWV 165
            ..|.:..|.|   .:.|.:.:...:|::..||::|.|...:.||:....|..|:.......:..:
Worm   105 SDPNSTVAVLSYNISASFMRLAEKVSVWFAVAIAVIRTLVMRYPVNGRINCLTQAKYGFRIVVLI 169

  Fly   166 AGTIVGF-LPLF---------GWHADVN---------------HNQECLFVEVMDYNYL-----V 200
            ...|:.| .|.:         ||....|               |:.| ||.....|...     :
Worm   170 TLLIIPFGAPSYFKLNSTSVRGWTPFTNCVTFSENSTKIKFDSHSTE-LFGSTDVYKIALLIEGI 233

  Fly   201 FLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDL--SRRSSAAVVQVTTPGRGGHTGT 263
            ||.|    ||::::                .|.|::...||  :|::|
Worm   234 FLEF----TPSIIL----------------PITTISLIMDLRKARKNS----------------- 261

  Fly   264 MLRVLGAARKRD-VKATQNLSIIVLFFMICWIPL---YTINCIKAFCPDCYVHPKLTLFCIILSH 324
             |....:|...| |::.:.::.:.:.|:....||   |.:.......|.  |...:|.|..:|:.
Worm   262 -LSTKSSASSSDAVRSIKLVAFVTITFLFTTTPLGFMYIVGIFIVKMPG--VIMIVTKFARVLTF 323

  Fly   325 LN--SAVNPVLYAY 336
            |.  |.:..:|..|
Worm   324 LTTLSGIAHILICY 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	42/213 (20%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	62/330 (19%)
srw-31	NP_507435.2	7TM_GPCR_Srw	36..354	CDD:370978	65/339 (19%)
		TM helix 2	66..91	CDD:341315	4/24 (17%)
		TM helix 3	116..146	CDD:341315	6/29 (21%)
		TM helix 4	160..180	CDD:341315	2/19 (11%)
		TM helix 5	224..249	CDD:341315	8/44 (18%)
		TM helix 6	276..302	CDD:341315	4/25 (16%)
		TM helix 7	315..340	CDD:341315	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910