DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and srw-143

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_503798.3	Gene:	srw-143 / 186788	WormBaseID:	WBGene00005890	Length:	368	Species:	Caenorhabditis elegans

Alignment Length:	355	Identity:	71/355 - (20%)
Similarity:	129/355 - (36%)	Gaps:	83/355 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 FEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMG--LPRNL 109
            :|..::|.||..|:...::..|:.......|..:..:::.|:    ..:.|.:..|.|  :....
Worm    39 YEHYLSIASIFINIFHFLILIRKPLRSSSINIIMAFISIFDI----CSMLFRMKQSYGPSIEYIF 99

  Fly   110 HACL-----FTVSLLVVLCTI-------SIFCLVAVSVDRYWAILYPM--AYSRNVRTRTAIF-I 159
            ..|:     |.|.|..:|..:       |.:.|.::::.|...|..||  .|.|.....|::| :
Worm   100 DPCMQSKWYFNVYLEKILLVVKDHSQRSSTWLLFSIALIRTLVIRNPMNPKYERLAHPPTSLFTM 164

  Fly   160 ISMCWVAGTIVGFLPLFGWHADV---NHNQECLFVEVMDYNYLVFLYF---ATIITPALLMLAFY 218
            |.:..:.|.| .....||  :|:   ||...|      |.:.::|.|.   |:......::|..|
Worm   165 ICINLIFGPI-SIATFFG--SDITSQNHTSSC------DPDGVLFYYLDISASYKQNDGMILKIY 220

  Fly   219 THIYRVIIKQVR----QIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRD-VKA 278
            |.|..|:...:.    .|||:....:|.:..:                ...|:..:.:..| .|.
Worm   221 TLINSVVSTIIPCFIFPIVTVFLVKELWKAEA----------------NRKRLFSSKKVNDSSKN 269

  Fly   279 TQNLSIIVLFFMICWIPL-YTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYA------- 335
            ||.:..:...|.|...|: .:|..       .|...:...|.|||..::...:.:|.|
Worm   270 TQLVLFLTCVFFIAQFPIGISIGA-------SYFFSETPGFMIILHEISYIFSVILVANTFSHFF 327

  Fly   336 ---YHLKDFRAALKNLL--------LKMMG 354
               :....:||.||..:        |:|.|
Worm   328 ICIFMSSQYRAELKKSIYCRTKAKVLQMNG 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	40/190 (21%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	58/304 (19%)
srw-143	NP_503798.3	7TM_GPCR_Srw	38..347	CDD:370978	68/343 (20%)
		TM helix 2	69..94	CDD:320109	5/28 (18%)
		TM helix 3	115..137	CDD:320109	3/21 (14%)
		TM helix 4	162..178	CDD:320109	4/16 (25%)
		TM helix 5	218..241	CDD:320109	6/22 (27%)
		TM helix 6	267..292	CDD:320109	6/24 (25%)
		TM helix 7	307..333	CDD:320109	3/25 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910