DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and srw-59

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_506996.1	Gene:	srw-59 / 186771	WormBaseID:	WBGene00005806	Length:	349	Species:	Caenorhabditis elegans

Alignment Length:	408	Identity:	78/408 - (19%)
Similarity:	155/408 - (37%)	Gaps:	130/408 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SKDAKDSDSPSSELNIPYTVFE------VLVAIVSIIGNVLVIIVFRRERKLRRRT-NYYIVSLA 84
            |.|.|:.|.....:.:.|.|.:      .::|::.:..|:..:||..| :.||..| |.:::.:|
Worm     6 SDDYKEFDFWDHIIILVYPVLDYQAHVKFVIAVIGVFVNIFHLIVLTR-KSLRVYTINIFLIGIA 69

  Fly    85 MAD----LLVGALGIP-------FAILASMGLPRNLHACLFTVSLLV-------VLCTISIFCLV 131
            :.|    |....|.:|       .:|::|:.:|...:|..|   |.|       |...::::..|
Worm    70 ICDFIRLLSYVLLALPDYHYRYQKSIMSSICIPPPSYASCF---LFVHFTPIPRVFQDLAVWFGV 131

  Fly   132 AVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGT-----IVGFLPLFGWHADVNHNQECLFV 191
            |::|.|    :..:.||.:::.:..|...|..|:...     ||.::..|.|            .
Worm   132 AMAVLR----VIILKYSLSLKAQNLISSNSGIWILFVVCLPHIVYWIFEFQW------------T 180

  Fly   192 EVMDYNY-------LVFLYFATII----------TPALLML--AFYTHIYRVIIKQVRQIV---- 233
            |:.:|..       ..|.|.:..|          ...||::  .|:|.|..:|:..|..::
Worm   181 EIREYGIWEIPSGCANFTYTSPRIIYSMGPEEYQNETLLLVEGIFFTLIPSIILPIVTIVLIYFL 245

  Fly   234 -TMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPL- 296
             ||       :||:|:       ....|              :.::|:.::::.:.|::..:||
Worm   246 KTM-------KRSTAS-------NNNNH--------------NARSTKMVALVTVTFLLATVPLG 282

  Fly   297 --YTINCIKAFCPDCYVHPK----LTLFC---IILSHLNSAVNPVLYAYHLKDFRAALKNLLLKM 352
              |           .|.|..    ::.||   :|:....|.:|..::........:..:.::.:|
Worm   283 ITY-----------LYQHTDFSFGISFFCSMFVIICEFVSLINGTMHFLLCVCISSQYQRIVREM 336

  Fly   353 MGVDIDQQAEAIHRFSVA 370
            .|       ..|:|.|||
Worm   337 FG-------RKINRISVA 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	43/210 (20%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	64/333 (19%)
srw-59	NP_506996.1	7TM_GPCR_Srw	31..340	CDD:370978	67/374 (18%)
		TM helix 1	34..53	CDD:320109	4/18 (22%)
		TM helix 2	62..84	CDD:320109	5/21 (24%)
		TM helix 3	113..135	CDD:320109	4/21 (19%)
		TM helix 4	160..176	CDD:320109	3/15 (20%)
		TM helix 5	216..239	CDD:320109	7/22 (32%)
		TM helix 6	261..286	CDD:320109	5/35 (14%)
		TM helix 7	301..326	CDD:320109	3/24 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910