DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and H09F14.1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001256232.1	Gene:	H09F14.1 / 186709	WormBaseID:	WBGene00010375	Length:	401	Species:	Caenorhabditis elegans

Alignment Length:	404	Identity:	89/404 - (22%)
Similarity:	149/404 - (36%)	Gaps:	108/404 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMAD--LLVGALGIPFAILASMGLPRNLHAC 112
            |:.|..:.|||:.::.....|..|...|.|::.|.:||  .|.|.|.|.|.:        :..|.
Worm    17 LIVIFGLSGNVISLVTIFHSRLRRVNANIYLIVLTLADSIFLTGILLICFKV--------DWIAY 73

  Fly   113 LFTVSLLVVLCT---ISIFCLVAVSVDRYWAILYP---MAYSRNVRTRTAIFIISMCWVAGTIVG 171
            .:.|.|..||.|   ||.:...|::::||.||.:|   |.|....|.:..::     ||....|
Worm    74 EYCVGLEYVLMTASYISSWSTAALTIERYLAIAHPLSHMKYGHVDRAKVMLY-----WVPIPFV- 132

  Fly   172 FLPLFGWHA--DVNHNQECLFVEVMDYNYLVFLYFA-TI---ITPALLMLAFYTHIYRVIIKQVR 230
             |.||.:.:  .....::|...|.   ||.:..... |:   :.|..:::.....:...:.|...
Worm   133 -LQLFQFFSLEPATEERKCALKEA---NYQIIAQAVDTVLCYVVPCGIIVVLNILVALQVQKSQE 193

  Fly   231 QIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIP 295
            ..:.....|: |||         |.|....:||..|:|.              ::.|.|::...|
Worm   194 HFMAETKKSN-SRR---------TGGSSSSSGTWTRILW--------------VMPLVFVVLNTP 234

  Fly   296 LYTINCIKAFCPDCYVHP-----KLTLFCII------LSHLNSAVNPVLYAYHLKDFRAAL---- 345
            .|.|..|:......|..|     :..||..:      :.::|:|::.::||:...:||...
Worm   235 FYVIMMIEIVFQIIYQSPPSGDTRSELFVTVYNTAHYMYYMNTAIDVLVYAFSSANFRKTAVIAW 299

  Fly   346 --------------KNLLLKMM---------GVDIDQQAEAIHRFSVASQ-----HRLQSMDSNM 382
                          |..||.|:         .:.|.|.|.  |...|..|     :|:.|..|.:
Worm   300 KRILCPGYAERQKGKRFLLSMVHSVSDSIRKRIPIAQPAP--HTVLVTDQTSRISYRMTSERSTI 362

  Fly   383 -------RSTQPRL 389
                   |:..|:|
Worm   363 RFPNTPSRANSPKL 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	45/181 (25%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	67/300 (22%)
H09F14.1	NP_001256232.1	7tm_GPCRs	10..295	CDD:391938	73/319 (23%)
		TM helix 1	10..36	CDD:341315	5/18 (28%)
		TM helix 2	43..67	CDD:341315	9/23 (39%)
		TM helix 3	77..106	CDD:341315	11/28 (39%)
		TM helix 5	158..183	CDD:341315	2/24 (8%)
		TM helix 6	212..242	CDD:341315	9/43 (21%)
		TM helix 7	263..288	CDD:341315	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910