DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and dmsr-1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_741629.1	Gene:	dmsr-1 / 186437	WormBaseID:	WBGene00010191	Length:	510	Species:	Caenorhabditis elegans

Alignment Length:	505	Identity:	91/505 - (18%)
Similarity:	171/505 - (33%)	Gaps:	111/505 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 YTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRN 108
            :....:.:.::..|.|...|:|..| |.:|...|..:.::|..|.:|....:.:....|....:.
Worm    34 HAYLSIFLCVLGTIANFCNIVVLTR-RTMRTPVNMILTAMASCDTVVLFSNLIYTTHYSFVAFKF 97

  Fly   109 LHACLFTVSLLVVLCTISIFCLVAVSVDRYWAIL-----YPMAYSR------NVRTRTAIFIISM 162
            .|...::.|..:.|...:...|||.|...:.:::     |....||      .|..|.:.:.::
Worm    98 CHPKHWSYSWALFLIAHAHLSLVAHSSSVWLSVMLALVRYVTLRSRGNMGGMQVTLRHSYYAVA- 161

  Fly   163 CWVAGTIVGFL-----------------------PLFGWH--------ADVNHNQECLFVEVMDY 196
              |..::|..|                       |:| |:        ||:.....||   |...
Worm   162 --VTVSLVAVLNAPNFLNYKINEQPLNETCTDLDPMF-WNSPAYLPGIADIAKANSCL---VFRL 220

  Fly   197 NY----LVFLYFATIITPALLMLAFYTHIYRVI--IKQVRQIVTMN-----PASDLSRRSSAAVV 250
            :|    :||.     :.|..|:..|...:.|::  :::.||.:..|     |....:|......:
Worm   221 SYWISGMVFK-----VLPCALLSLFVWLLLRILREVRENRQRLLKNSQHRPPNQTTTRNGQRLSI 280

  Fly   251 QVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPD---CYVH 312
            .|....:.|..|: ||..|   :|..:.|..|..||...::..:|...:..:...|.:   .|::
Worm   281 SVAGNEKLGRNGS-LRGRG---ERVDRTTHMLLAIVAVMLVTELPQGIMAVLSGMCSEEFRIYIY 341

  Fly   313 PKLTLFCIILSHLNSAVNPVLYAYHLKDFR-------AALKNLLLKMMGVDIDQQAEAIHRFSVA 370
            ..|.....:.|...|..:.::|......||       ...|...|:|....|.:.::|   :|..
Worm   342 NNLGDILDLFSLCGSCCSFIIYCSMSGQFRNEFHRVFVPAKVRCLRMSSPSIRRPSDA---YSTT 403

  Fly   371 SQHRLQSMDSNMRSTQPRLYVGEYSP-----------IWLRQQQEALKNSQLLPKCGVVSPCFNN 424
            ....|:..:.|.......   |.||.           |.:|:....:..   :..|..::||
Worm   404 KMTFLKPNEKNGNGMNGN---GTYSEDTRSASVKMVGIQVRRNSTEITR---MTGCDSITPC--- 459

  Fly   425 INQTVAAVASVTTDLEREMWNIVEASSGAELGETSYEFPSPAPGSQRSSE 474
                    :.:.|.........:.:.......|||:...|..|.|..|::
Worm   460 --------SPMPTSFPSSPLPPIRSGEDESTDETSHLLNSSGPNSTASAD 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	41/213 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	63/331 (19%)
dmsr-1	NP_741629.1	7tmA_FMRFamide_R-like	32..374	CDD:410630	67/356 (19%)
		TM helix 1	34..58	CDD:410630	4/23 (17%)
		TM helix 2	66..88	CDD:410630	4/21 (19%)
		TM helix 3	112..134	CDD:410630	4/21 (19%)
		TM helix 4	158..174	CDD:410630	3/18 (17%)
		TM helix 5	219..242	CDD:410630	6/27 (22%)
		TM helix 6	305..327	CDD:410630	5/21 (24%)
		TM helix 7	342..367	CDD:410630	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910