DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and frpr-8

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_509470.3	Gene:	frpr-8 / 186144	WormBaseID:	WBGene00018728	Length:	434	Species:	Caenorhabditis elegans

Alignment Length:	359	Identity:	76/359 - (21%)
Similarity:	144/359 - (40%)	Gaps:	98/359 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PSSELNIPY-TVFEVLVAI--VSIIG---NVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALG 94
            |::...:.| :.:..|:||  :.::|   .|:.|:||.| :::|...|.|:..|::.||::
Worm    33 PTNFAEVDYISTYIYLLAIPTICVLGAGAAVMCIVVFTR-KQMRSSLNVYLAGLSVFDLIL---- 92

  Fly    95 IPFAILASMGLPRNLHACL------------------FTVSLLVVLCTISIFCLVAVSVDRYWAI 141
            :.|:.|    :...|..|:                  :|:.:..:....|::..|||:|||:.|:
Worm    93 LSFSAL----IFSPLQGCVLQGHGDTAVCHFFWRSTPWTLPISNIAQCGSVWTCVAVTVDRFLAV 153

  Fly   142 LYPMAYSRNVRTRTAIFIISMCWVAGTIVGFL---PLFGWHADVNHNQEC-----LFVEVMDY-- 196
            .||:........|.|..|:    :|.|:...|   |:|   .::. |.:|     .|:....|
Worm   154 NYPLHSKIWCTPRRATTIL----IAITVFSILFKAPMF---FELT-NDDCGRLRTSFLRDNKYYK 210

  Fly   197 -NYLVFLY-FATIITPALLMLAFYTHIYRVIIK--QVRQIVT--MNPASDLSRRSSAAVVQVTTP 255
             .|:.|.| .|.::.|..:|:.....:.:.:.|  ::|:.:.  .|...:..||.:...:.:..
Worm   211 EYYVTFGYLIALLLIPWTVMIILNVFVVKAVHKAYKIRRSMQGGKNNQEEKDRRCTLMAIAMVL- 274

  Fly   256 GRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMI-CWIPLYTINCIKAFCPDCYVHPKLTLFC 319
                 |..:..|        |.|..||:..|....: .|.|:..:                 |.|
Worm   275 -----TFLIFNV--------VAAVNNLAETVFEVSLGFWSPIGNL-----------------LIC 309

  Fly   320 IILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMM 353
                 ||||.|.|:|:.    |.|..:.:.:.|:
Worm   310 -----LNSASNIVIYSL----FGARFRQMCVLML 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	47/202 (23%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	67/313 (21%)
frpr-8	NP_509470.3	7tmA_FMRFamide_R-like	45..330	CDD:320109	73/341 (21%)
		TM helix 1	47..71	CDD:320109	8/23 (35%)
		TM helix 2	79..101	CDD:320109	7/29 (24%)
		TM helix 3	125..147	CDD:320109	5/21 (24%)
		TM helix 4	170..186	CDD:320109	4/19 (21%)
		TM helix 5	212..235	CDD:320109	6/22 (27%)
		TM helix 6	263..288	CDD:320109	6/38 (16%)
		TM helix 7	301..323	CDD:320109	10/47 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910