DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and srw-51

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_507344.1	Gene:	srw-51 / 185526	WormBaseID:	WBGene00005798	Length:	352	Species:	Caenorhabditis elegans

Alignment Length:	359	Identity:	60/359 - (16%)
Similarity:	139/359 - (38%)	Gaps:	100/359 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 YTVFEVLVAIVSIIGNVL----VIIVFRRERKLRRRT-NYYIVSLAMADLLVGALGIPFAILASM 103
            |:....::.:|||||.:|    .:::||  :.:|:.| |.:::.:|:.|.   :..|.|.::.:.
Worm    18 YSYLNYVIFVVSIIGIILNVFHFLVLFR--KSMRQLTINIFMIGIAICDF---SQMISFVVVMTS 77

  Fly   104 GLPRNLHA------C-------------LFTVSLLVVLCTISIFCLVAVSVDRYWAILYP----- 144
            ....|...      |             :||. :..|...::::..|::::.|...|.:|
Worm    78 QFYINYKTTQISPECYPPQSYIEYKINHIFTF-ISNVSPKLAVWLGVSLAILRASVIRHPTNSSI 141

  Fly   145 --MAYSRN-VRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHN-----QEC-----------LF 190
              ..||:: :|....|.:...|:       |:..:..|:.....     .||           .:
Worm   142 QNYIYSKHGIRILLTICLPYACY-------FIYDYTAHSTTISETWELPPECANTSEPDTYTLYY 199

  Fly   191 VEVMDYNYLVFLYFATI---ITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQV 252
            .|..:.::.:.|:...|   :.|::| |..:|.:....:|:.|::.|.
Worm   200 TEYDESSFRISLFIDGILFKLIPSIL-LPLFTIVLLYEMKKTRKVATS----------------- 246

  Fly   253 TTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYV----HP 313
                         |....:..:| ::|:.::.:.:.|::..:||..:..||:......|    ..
Worm   247 -------------RSFQNSNSKD-RSTKLVTFVTITFLLSTVPLGILYIIKSIFLQSLVISNFAN 297

  Fly   314 KLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKN 347
            ||....:::|.:|..::.::..:....:|..:||
Worm   298 KLQSIFVLISIINGTLHFLICFFMSSQYRNTVKN 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	39/218 (18%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	52/330 (16%)
srw-51	NP_507344.1	7TM_GPCR_Srw	23..336	CDD:370978	59/354 (17%)
		TM helix 1	23..45	CDD:320109	6/21 (29%)
		TM helix 2	54..76	CDD:320109	5/24 (21%)
		TM helix 3	105..127	CDD:320109	4/22 (18%)
		TM helix 4	152..168	CDD:320109	4/22 (18%)
		TM helix 5	208..231	CDD:320109	5/23 (22%)
		TM helix 6	256..281	CDD:320109	5/25 (20%)
		TM helix 7	297..322	CDD:320109	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910