DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and srw-4

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_503785.3	Gene:	srw-4 / 185414	WormBaseID:	WBGene00005751	Length:	367	Species:	Caenorhabditis elegans

Alignment Length:	381	Identity:	75/381 - (19%)
Similarity:	130/381 - (34%)	Gaps:	127/381 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TVFEVLVAIVS--IIGNVLVIIVFRR--ERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGL 105
            :|:.:::.|.|  ||.:.|..:.|..  .|::|::.....:::...|          |:|
Worm    62 SVYRLMIGICSCDIISHTLTFLAFSPFWIREVRKKNQECFLTMTYRD----------AVL----- 111

  Fly   106 PRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIV 170
                  .|:.|.:|.:....|.:..|.:::.|..::.|||:...:.       :.:..|...||:
Worm   112 ------LLYPVIVLDITQRSSSWLAVLMALYRTLSVKYPMSTKMHK-------VSNPKWALWTII 163

  Fly   171 GF--------LPLFGWHADVNHNQECLFVEVMDYN------YLVFLYFATIITPALLML-AFYTH 220
            |.        |.:||.|.....|        :||:      :|..|.|..::..:|..| :..|.
Worm   164 GVLVVNTAWTLVVFGRHKIDGRN--------IDYDCDGNEVHLSQLRFMVLVDTSLEHLHSIITS 220

  Fly   221 IYRVI---------IKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDV 276
            ||.:|         |..|..|:.:..||  .||.:..                        |.|.
Worm   221 IYGIIKALPSLIDPILTVLLIIELRKAS--KRRKNIG------------------------KEDC 259

  Fly   277 KATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDF 341
            ..:.|.:.:|||..|.:..|..        |:.:.|.....|     |.|..:..:.|.
Worm   260 GKSDNTTKLVLFVTISFFILEV--------PNGFAHVTAGAF-----HGNPGILTISYM------ 305

  Fly   342 RAALKNLLLKMMGVDIDQQAEAIHRFSVASQHRL--QSMDSNMRSTQPRLYVGEYS 395
                           |...||.:..|: :|.|..  .:|.|..|.|...::.||.|
Worm   306 ---------------IQVFAEILPVFN-SSSHIFICLAMSSQYRETSCEIFCGEKS 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	36/186 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	56/301 (19%)
srw-4	NP_503785.3	TM helix 1	33..55	CDD:320109
		7TM_GPCR_Srw	37..341	CDD:370978	72/375 (19%)
		TM helix 2	64..86	CDD:320109	5/21 (24%)
		TM helix 3	113..135	CDD:320109	5/21 (24%)
		TM helix 4	160..176	CDD:320109	4/15 (27%)
		TM helix 5	213..238	CDD:320109	6/24 (25%)
		TM helix 6	263..288	CDD:320109	7/32 (22%)
		TM helix 7	303..329	CDD:320109	7/47 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910