DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and srw-57

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_506997.2	Gene:	srw-57 / 185365	WormBaseID:	WBGene00005804	Length:	356	Species:	Caenorhabditis elegans

Alignment Length:	393	Identity:	65/393 - (16%)
Similarity:	139/393 - (35%)	Gaps:	123/393 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 NIPYTVFEV---------LVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIP 96
            ||..|:..:         |||::.::.|:..:||..|:.......|.:::.:|:.|.    |.:.
Worm    24 NIMQTIIPIFEHQSHLDFLVAVIGVLVNIFHLIVLSRKSMRLYTINLFLIGIAICDF----LRLI 84

  Fly    97 FAILASMG----------LPRNLHACLFTVSLLVVLCTISI--------FCL-VAVSVDRYWAIL 142
            |.:|.::.          :|.:.......:|..|.:.:|:|        .|. ||::|.|...:.
Worm    85 FNVLVALSNYYHKYQTSIMPEDCTPPKSWLSFFVSVHSITIPRIFQKLAVCFGVAMAVLRVIILK 149

  Fly   143 YPM-AYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADV------------------NHNQEC 188
            ||: ...:|::..::    .:|.:....:..:|.  |..|:                  |.|...
Worm   150 YPLNRRGQNLKRSSS----GICILLIVCIPHIPF--WFFDLQWTEIQENGIWKPPPGCENFNDHN 208

  Fly   189 LFVEVM----DYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAV 249
            |.:|..    :|:....|....:             ::.||...:..||
Worm   209 LHIEYSVKPGEYSSETLLRIEGV-------------LFTVIPSLILPIV---------------- 244

  Fly   250 VQVTTPGRGGHTGTMLRVLGAARK--------RDVKATQNLSIIVLFFMICWIPL---YTINCIK 303
                       |||::......:|        .:.::|..::::.:.|:|...||   |.::.:.
Worm   245 -----------TGTLIYFFKTLKKSTSSRNNDHNARSTIMVTLVAVTFVIATFPLLLTYLVDFLS 298

  Fly   304 AFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFS 368
            ......:.......||..:|.:|..::.:|.|:....::..::    :|.|       ..|.|.:
Worm   299 LGYRLAFFIILFGAFCEFVSLINGTLHFLLCAFISTQYQKTVR----EMFG-------RKISRIT 352

  Fly   369 VAS 371
            ||:
Worm   353 VAT 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	34/209 (16%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	51/328 (16%)
srw-57	NP_506997.2	7TM_GPCR_Srw	38..347	CDD:370978	58/369 (16%)
		TM helix 1	41..60	CDD:320109	6/18 (33%)
		TM helix 2	69..91	CDD:320109	6/25 (24%)
		TM helix 3	120..142	CDD:320109	5/21 (24%)
		TM helix 4	164..179	CDD:320109	1/18 (6%)
		TM helix 5	223..246	CDD:320109	5/62 (8%)
		TM helix 6	268..293	CDD:320109	5/24 (21%)
		TM helix 7	308..333	CDD:320109	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910