DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and npr-7

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_509570.3	Gene:	npr-7 / 185321	WormBaseID:	WBGene00018067	Length:	380	Species:	Caenorhabditis elegans

Alignment Length:	385	Identity:	86/385 - (22%)
Similarity:	159/385 - (41%)	Gaps:	102/385 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SITDFSFEGPLLP--LHAATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGN--VLVIIVFRR 68
            ::|||..|.|.:.  :|..|.             |.:.|.    ||..:|::||  ||:|::.||
Worm     6 NLTDFQCEYPAIDIGIHMKTL-------------LAVGYG----LVGALSLVGNLAVLLIVICRR 53

  Fly    69 ERKLRRRTNYYIVSLAMADLLVGALGI---PFAILASMGLPRNLHACLFTVSLLVVLCTISI--- 127
            |  ::..||.:|.|::.|||::.:..:   |.|.     ..|..|...:...::.::..:|:
Worm    54 E--MQTVTNIFISSVSAADLVITSFSLWATPLAY-----YQRVWHFGKYMCYMVSIIQGLSLMWV 111

  Fly   128 -FCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAG--------TIVGFLPLFG------ 177
             ..|.||::|||..:..|  :.:.:..:|.:.||:..|:.|        .:|.|:..:|
Worm   112 PLTLAAVALDRYSLVASP--FRQPMSKKTCLLIIAGIWMGGFAVLSPMIRMVDFVDSYGPCHFCL 174

  Fly   178 --WHADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASD 240
              |..|..|.:  ||     |...|.:..:.|  |.:|:...:..|..::..|.::..|:
Worm   175 ESWDHDKQHYR--LF-----YGLSVLVIRSAI--PLVLISLCHWRIAVILNTQTKKFQTL----- 225

  Fly   241 LSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSII----VLFFMICWIPLYTINC 301
               ||::.|.|.|                     |::..|.|..:    |:.|.:..:||...|.
Worm   226 ---RSASTVTQST---------------------DIRRKQRLQTLLLAMVVIFAVSSLPLDLSNV 266

  Fly   302 IKAFCPDCYVHPK-------LTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMG 354
            ::.......|.|.       :..||...:...:.:||::|||:.::||..::....:|.|
Worm   267 LQDLIVVYQVRPVPDNVRHFIFFFCHWTAMAGTLLNPLVYAYYNENFRRQIQTCFGEMRG 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	46/192 (24%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	67/311 (22%)
npr-7	NP_509570.3	7tmA_NPYR-like	25..317	CDD:320331	78/355 (22%)
		TM helix 1	27..51	CDD:320331	10/27 (37%)
		TM helix 2	60..82	CDD:320331	6/21 (29%)
		TM helix 3	98..120	CDD:320331	4/21 (19%)
		TM helix 4	141..157	CDD:320331	4/15 (27%)
		TM helix 5	186..209	CDD:320331	7/29 (24%)
		TM helix 6	241..266	CDD:320331	6/24 (25%)
		TM helix 7	285..310	CDD:320331	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910