DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and srw-29

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_507151.2	Gene:	srw-29 / 184965	WormBaseID:	WBGene00005776	Length:	361	Species:	Caenorhabditis elegans

Alignment Length:	338	Identity:	62/338 - (18%)
Similarity:	124/338 - (36%)	Gaps:	94/338 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 IVSIIGNVLVII---VFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNLHACLF 114
            :|.|:|..|.:|   |..|:.......|.:::.:|:|| ::.::.|.|.....:....|...||:
Worm    40 VVPILGAFLGLIHLTVLTRKCMRTLGINIFLIGIAIAD-MIRSISINFTPFFYLRYLSNEVLCLY 103

  Fly   115 ---------TVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRT--------------- 155
                     :.|.:.:...:||:..||::|.|...:.||:....|..|:.
Worm   104 PNSTLSYNISASSVKISEALSIWFGVAIAVIRSLVMRYPVNNRINRLTQVEYSLKIIITITMFAF 168

  Fly   156 ---AIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYL---VFLYFATIITPALLM 214
               |::...:|  :..:.|::|....|. .:.|...:.:: ...|.|   ..:|...::...:|:
Worm   169 PIWALYYTKLC--SAKVPGWMPFTNCHR-FSENSTKISID-FQINRLFGSTLIYEIDLLIEGVLL 229

  Fly   215 LAFYTHIYRVIIKQVRQIVTMNPASDL--SRRSSAAV-----------------------VQVTT 254
                    .:|...:..|.|:....||  ::::|.::                       :..||
Worm   230 --------ELIPSIILPITTIGLVKDLKEAQKNSMSIKSSTKSHDTLRSIKLVTFMTISFLFTTT 286

  Fly   255 PGRGGH-------------TGTMLRVLGAARKRDVKATQN-LSIIVLFFMICWIPLYTINCI--- 302
            |    |             .|.::.:|..||......|.| ::.|::.:::......|.|.:
Worm   287 P----HGLMYVIGMFNTDKPGLVMIILKFARLFTFLTTLNGIAHILICYLMSTQYRNTANEVFGE 347

  Fly   303 --KAFCPDCYVHP 313
              |.|.|...|||
Worm   348 GRKIFKPTSLVHP 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	37/199 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	60/333 (18%)
srw-29	NP_507151.2	7TM_GPCR_Srw	36..346	CDD:370978	56/322 (17%)
		TM helix 2	66..92	CDD:341315	6/26 (23%)
		TM helix 3	110..140	CDD:341315	7/29 (24%)
		TM helix 4	154..185	CDD:341315	2/32 (6%)
		TM helix 5	218..243	CDD:341315	5/32 (16%)
		TM helix 6	265..295	CDD:341315	4/33 (12%)
		TM helix 7	309..334	CDD:341315	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910