DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and srw-44

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_507223.1	Gene:	srw-44 / 184480	WormBaseID:	WBGene00005791	Length:	385	Species:	Caenorhabditis elegans

Alignment Length:	392	Identity:	83/392 - (21%)
Similarity:	147/392 - (37%)	Gaps:	101/392 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LPLHAATTSKDAK------DSDSPSSELNIPYTVFEV---------LVAIVSIIGNVLVIIVFRR 68
            :|...:|.:||:.      |.:|.....:|...|.||         ::|.|...||:..:.|..|
Worm     1 MPNSKSTENKDSHSIFDIFDLESEDFWYSIWILVREVKWYIDLASLVIAFVGFFGNIFHLAVLTR 65

  Fly    69 ERKLRRRTNYYIVSLAMADL------LVGALGIPFAILASMGL-------PRNLHACLFTV--SL 118
            :.......:.:::|:|:.|.      :|....|.:....|:.:       |..|...:..|  ||
Worm    66 KSMRILSVSTFLISIAICDFVRMMSTIVTLSPIFYREYLSLHVRLKCQPPPSYLEMYIIYVFHSL 130

  Fly   119 LVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIIS-MCWVAGTIVGFLPLFGWHADV 182
            ..|...:|::..|.:::.|..||.||:    |.|.::.|...| :|.|....:..||..
Worm   131 ETVSMNLSVWFAVFMTIFRALAIRYPL----NKRIKSLITSESGLCTVITITILILPFC------ 185

  Fly   183 NHNQECLFVEVMDYNYLVFLYFATIITPALLMLAF---YTHI-YRV---------------IIKQ 228
                 ||..      :|..|:.|:...|:.....|   ||.| ||:               |:::
Worm   186 -----CLSF------FLRTLFPASTWYPSPGCKKFSKGYTQIQYRLLATELSGELGTETSEIMQK 239

  Fly   229 VRQIV-TMNPASDLSRRSSAAVVQV-------TTPGRGGHTGTMLRVLGAARKRD-VKATQNLSI 284
            |..:: ...|:..||..:.|.|..:       .|||               .|.| .|.|:.:|.
Worm   240 VEGLLFKFLPSVVLSLATFALVFAIRKHKKKNCTPG---------------NKSDKEKTTKLVSF 289

  Fly   285 IVLFFMICWIP---LYTINCIKAFCPDCY--VHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAA 344
            :...|:|..:|   |:.| ..|.|.....  |..:|:.....||.:|..::.::..:...::|..
Worm   290 VTFTFLIAIVPQGILFMI-MFKVFETSMMGAVIDELSTALSFLSVINGTIHLLIIYFMCSEYRKT 353

  Fly   345 LK 346
            ::
Worm   354 IR 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	41/186 (22%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	70/324 (22%)
srw-44	NP_507223.1	TM helix 1	41..65	CDD:320109	5/23 (22%)
		7TM_GPCR_Srw	44..361	CDD:370978	73/349 (21%)
		TM helix 2	74..96	CDD:320109	4/21 (19%)
		TM helix 3	125..147	CDD:320109	6/21 (29%)
		TM helix 4	172..188	CDD:320109	5/26 (19%)
		TM helix 5	235..258	CDD:320109	5/22 (23%)
		TM helix 6	282..306	CDD:320109	7/23 (30%)
		TM helix 7	322..347	CDD:320109	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910