DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and nmur-3

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001024524.1	Gene:	nmur-3 / 184090	WormBaseID:	WBGene00017176	Length:	445	Species:	Caenorhabditis elegans

Alignment Length:	389	Identity:	81/389 - (20%)
Similarity:	152/389 - (39%)	Gaps:	81/389 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KDSDSPSSE--------------LNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIV 81
            |..|.|..:              ||...|:..|.|.:|.:|||:|.:||..:...|...|||::.
Worm    51 KSLDHPGEQFNNSSNQLLLDRAFLNPILTLIFVFVGLVGLIGNLLTVIVIFKTNSLHSHTNYFLA 115

  Fly    82 SLAMADLLVGALGIPFAILASMGLPRNLHA---CLFTVSLLVVLCTISIFCLVAVSVDRYWAILY 143
            :||.:|..:..:|:.|.::........|..   |..|.:.:.:....||..:|.::.:|:.||.|
Worm   116 NLATSDFCLIVVGVSFDLVNIWNDEEPLDIFGYCSLTSTFISLFTFASILTIVLLTAERFTAICY 180

  Fly   144 PMAYSRNV--RTRTAIFIISMCWVA---GTIVGFL------PLFGWHADVNHNQECLFVE----- 192
            |.:: |.:  ..|...||:.:.:||   ...:|.:      ...|::..:.:...|..|.
Worm   181 PFSH-RTIFDEKRVKRFILLIWFVALLPSIFIGSMFKRVSQDFCGFNRQMTYIGRCDLVTSPDSF 244

  Fly   193 -------------VMDYNYLVFLYFATIITPALLM----LAFYTHIYRVIIKQVRQIVTMNPASD 240
                         |:...::::.||..:.|...|.    |::.::|:.|.:.::.....::....
Worm   245 FRYPFESAITITFVLPLFFIIYCYFRILGTRHFLCITVNLSYTSNIFPVTLNEMSNSTHVHTPVG 309

  Fly   241 LSRRSSAAVVQVTTPGRGGHTGTMLRVLGA------------ARKRDVKATQNLSIIVLFFMICW 293
            .:|..|.|   ...|....::.|....|..            |:|..:|.   |..:...|.:|:
Worm   310 TARSDSGA---FPFPHTSNNSNTQSFPLTVHTKNVQPPRSQQAQKMVIKM---LVTVTAVFFVCY 368

  Fly   294 IPLYTINCI-KAFCPDCYVHPKLTLFCI-------ILSHLNSAVNPVLYAYHLKDFRAALKNLL 349
            :|.:....| |....||    ..:.||.       ||.::::::||:.|......||...|.|:
Worm   369 LPYHAQRLIVKYNSKDC----SNSDFCKLLYPIAGILQYISASLNPIFYNLMSVRFRNGFKKLI 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	43/203 (21%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	66/331 (20%)
nmur-3	NP_001024524.1	7tmA_NTSR-like	76..424	CDD:320110	74/358 (21%)
		TM helix 1	78..102	CDD:320110	10/23 (43%)
		TM helix 2	111..133	CDD:320110	7/21 (33%)
		TM helix 3	150..172	CDD:320110	4/21 (19%)
		TM helix 4	195..211	CDD:320110	4/15 (27%)
		TM helix 5	246..269	CDD:320110	1/22 (5%)
		TM helix 6	351..376	CDD:320110	6/27 (22%)
		TM helix 7	392..417	CDD:320110	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910