DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and dmsr-4

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001368505.1	Gene:	dmsr-4 / 183924	WormBaseID:	WBGene00017038	Length:	386	Species:	Caenorhabditis elegans

Alignment Length:	394	Identity:	66/394 - (16%)
Similarity:	121/394 - (30%)	Gaps:	157/394 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 YTVFE----VLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLL--------------- 89
            ||.|.    :.:.||.:..|.:.|.|..|.|..|...|..:.::|..|::
Worm    38 YTYFHRYACLFICIVGVFSNAIHIAVLSRPRMRRCAVNSVLTAVAFCDVITMTSYSIYLMRFRFY 102

  Fly    90 --------VGALGIPFAILASMGL----------------------------PRNLHACLFTVSL 118
                    :..:.:.|.:.:||.|                            |||.......||:
Worm   103 ETDHGYSYIWLVFLKFHVWSSMTLHAITLYMGGALAFIRWQALGNIHSKWLQPRNSWQLFGVVSV 167

  Fly   119 LVVLCTISIFCLVAVSVDRYWAILYP---------------------MAYSRNVRTRTAIFIISM 162
            :     :||.||..:.:.:.:.|..|                     :.||.|..|.:..|....
Worm   168 V-----LSIVCLPTLVLHKIYEIESPEIETSTVSEVLRLSGQSIPKEVRYSLNFSTYSCAFFKFN 227

  Fly   163 CWVAGTIVGFLP--LFGWHADVNHNQECLFVEVMD----YNYLVFLYFATIITPALLMLAFYTHI 221
            .|:...::..:|  |..|..      ..|.|::..    .|||                  |:..
Worm   228 LWMLAIVLKAIPCALLLWFT------IALVVKLRQTDEKRNYL------------------YSKS 268

  Fly   222 YRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIV 286
            :|..:|                       :.|.|.|                    .|..|.|::
Worm   269 FRKHVK-----------------------KTTVPDR--------------------TTYMLIIML 290

  Fly   287 LFFMICWIP---LYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNL 348
            :.|::..:|   |..:|.:.....:.|::..|:.....||.:|.:|:.:||......:|....::
Worm   291 VVFLVTELPQGFLALLNGLYTGDVNIYIYKNLSELLDFLSLINCSVDFLLYCVMSSRYRQTFGHM 355

  Fly   349 LLKM 352
            |:::
Worm   356 LIRV 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	41/245 (17%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	57/356 (16%)
dmsr-4	NP_001368505.1	7tmA_FMRFamide_R-like	40..352	CDD:410630	63/383 (16%)
		TM helix 1	42..66	CDD:410630	5/23 (22%)
		TM helix 2	75..97	CDD:410630	3/21 (14%)
		TM helix 3	117..139	CDD:410630	4/21 (19%)
		TM helix 4	160..176	CDD:410630	6/20 (30%)
		TM helix 5	225..248	CDD:410630	4/28 (14%)
		TM helix 6	283..305	CDD:410630	6/21 (29%)
		TM helix 7	320..345	CDD:410630	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910