DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and D1014.2

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_505101.3	Gene:	D1014.2 / 183895	WormBaseID:	WBGene00017015	Length:	337	Species:	Caenorhabditis elegans

Alignment Length:	356	Identity:	77/356 - (21%)
Similarity:	138/356 - (38%)	Gaps:	70/356 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 VAIVSII----GNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNL-- 109
            |.|:.||    ||:|.::|. ..|.:|.|||....::|.|||....|.|| ::|..:|..|:.
Worm    29 VLILQIIFGCGGNILNLMVL-LSRAMRSRTNLIFAAMAFADLFFLILHIP-SVLFFIGTIRDAPW 91

  Fly   110 HACLFTVSLLVVL---CTISIFCLVAVSVDRYWAILYPMAYS-RNVRTR--TAIFIISMCWVAGT 168
            :...|:..:..:|   ..:||:.::..:::|......|...| |:..||  ..:|.|:...:..|
Worm    92 YRNGFSQVIAGMLNWSSAVSIWFMMYATIERVQVFRSPFRTSKRSASTRFFITLFSIAFFCLLLT 156

  Fly   169 IVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIV 233
            ||.|:     |.......:  :...:.|.:::|:    :|.|..|..:....:...:.|....:.
Worm   157 IVHFI-----HPKTRAANK--YARYVVYIHMIFV----VIIPMFLSTSLNILLVCALRKNSMPLR 210

  Fly   234 TMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYT 298
            .:|.    |....:.:||.|...|                   |.|..:::|:..|:.|.:|...
Worm   211 MLND----SHVHQSLIVQRTRTER-------------------KVTAMVTVILSSFIACNVPGSI 252

  Fly   299 INCIK----AFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQ 359
            :..:|    .| .|...|..:...|..|:.....:|.:|:....:.|||.||..|..:..:
Worm   253 VFVMKESDDTF-DDSRRHILMQAVCNSLAVTGKVLNFLLFCLSSEHFRALLKKRLCYLFHL---- 312

  Fly   360 QAEAIHRFSVASQHRLQSMDSNMRSTQPRLY 390
                         |...|...||.:|..:.:
Worm   313 -------------HHDSSRRHNMSTTATKTF 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	44/179 (25%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	61/287 (21%)
D1014.2	NP_505101.3	7tmA_FMRFamide_R-like	24..302	CDD:320109	69/309 (22%)
		TM helix 1	26..50	CDD:320109	8/21 (38%)
		TM helix 2	58..80	CDD:320109	8/22 (36%)
		TM helix 3	98..120	CDD:320109	3/21 (14%)
		TM helix 4	143..159	CDD:320109	4/15 (27%)
		TM helix 5	173..196	CDD:320109	5/26 (19%)
		TM helix 6	230..255	CDD:320109	7/43 (16%)
		TM helix 7	270..295	CDD:320109	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910