DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and npr-35

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001023088.1	Gene:	npr-35 / 183681	WormBaseID:	WBGene00016842	Length:	381	Species:	Caenorhabditis elegans

Alignment Length:	369	Identity:	92/369 - (24%)
Similarity:	149/369 - (40%)	Gaps:	95/369 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PLHAATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLA 84
            ||:|.....:.......|.:|.:.|||....|....::||..|::.....:.|...|:|.|:|||
Worm     8 PLYADVEQLEPVPLLRHSYQLTVLYTVAYGAVFFTGVLGNTFVVLAVWAHKNLNITTDYLILSLA 72

  Fly    85 MADLLVGALGIPFAILASMGLPRNLHACLFTVSLL-VVLCTI-----------SIFCLVAVSVDR 137
            :|||.:..:.:|..::.|          :||..|. ...|.:           |::.||||:.||
Worm    73 LADLFILWICLPTTLINS----------IFTEWLWGQFFCRLSTWANASTSFASVYTLVAVTADR 127

  Fly   138 YWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNY---- 198
            |.||.:.:.|:.:.......::|...|:...|.| :|  .|     :|.:.:..:...|.|
Worm   128 YLAICHTLKYNTSWDREYTKYVIFAVWLVAAIFG-IP--NW-----YNYDLIVWQEGSYGYRLCT 184

  Fly   199 ------LVFLY---FATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTT 254
                  |.||:   ....|.|..|:...||.|:          :|::
Worm   185 SQTDQKLYFLFVNLLLAFIVPFGLISGLYTRIF----------ITVS------------------ 221

  Fly   255 PGRGGHTGTMLRVLGAARKRDVK---ATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLT 316
                  |...|.|...||:..||   ||..|::|:: |..||:|||.|.....|..|    .:..
Worm   222 ------THRSLAVDARAREDRVKLRVATMMLTVIIV-FACCWLPLYCIFTYFFFFAD----QRSD 275

  Fly   317 LFCII----------LSHLNSAVNPVLYAYHLKDFRAALKNLLL 350
            ||.|.          :|.|:|::||::|..:...:|.|.|::||
Worm   276 LFQITSMLIRPIFQWMSLLSSSLNPIIYIAYSHKYRRAFKSILL 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	46/192 (24%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	77/313 (25%)
npr-35	NP_001023088.1	7tm_GPCRs	30..314	CDD:391938	83/340 (24%)
		TM helix 1	31..57	CDD:341315	7/25 (28%)
		TM helix 2	64..90	CDD:341315	10/25 (40%)
		TM helix 3	102..132	CDD:341315	10/29 (34%)
		TM helix 4	146..164	CDD:341315	5/20 (25%)
		TM helix 5	190..215	CDD:341315	7/24 (29%)
		TM helix 6	236..267	CDD:341315	13/31 (42%)
		TM helix 7	282..307	CDD:341315	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910