DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and nmur-1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_509515.3	Gene:	nmur-1 / 183574	WormBaseID:	WBGene00016747	Length:	400	Species:	Caenorhabditis elegans

Alignment Length:	383	Identity:	71/383 - (18%)
Similarity:	148/383 - (38%)	Gaps:	91/383 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMG---LP 106
            |...:.:.:|.:|||....:|.::...::...:.|:::||::||:...:|:||.::.:..   .|
Worm    55 TALYIFIFLVGVIGNTTTCLVMKKHPMMKTHASMYLMNLAVSDLVTLCVGLPFEVMMNWNQYPWP 119

  Fly   107 RNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPM------AYSRNVRTRTAIFIISMCWV 165
            ...:.|.....:.....::||..::..:::||.|:.:|:      .:.||:
Worm   120 FPDYICNLKALIAETTSSVSILTILIFAIERYVAVCHPLFLMKVQPFKRNI-------------- 170

  Fly   166 AGTIVGFLPLF-------------------GW-----HADVNHNQEC----LFVEVMDYNYLVFL 202
             |||:||..:|                   .|     ...|..::.|    :|...:...:.:..
Worm   171 -GTIIGFTWIFSILCAMPFAIHHRADYIMKSWPGTDNRIPVKSSKMCMIAVMFEPKLASTFKILF 234

  Fly   203 YFATIITPALLMLAFYT-HIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLR 266
            :|:.|        ||:. .::.::|...|....:         ||...:|   ||.
Worm   235 HFSAI--------AFFALPLFTIVILYARIACKV---------SSNRTIQ---PGE--------- 270

  Fly   267 VLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPD-----CYVHPKLTLFCIILSHLN 326
             |....:..::....|..||..|.||::| :.:..:..|..|     .:|:..:......|.:|.
Worm   271 -LDITEELQMRINAILCAIVSAFFICYLP-FQLQRLLFFYFDNEVILTWVNQYMYFISGFLFYLA 333

  Fly   327 SAVNPVLYAYHLKDFRAALKNLLLK--MMGVDIDQQAEAIHRFSVASQHRLQSMDSNM 382
            :.:||:.|......||.|.|::|:.  ..|........:..::|:|.....|:|.:.:
Worm   334 TIINPIAYNLASSRFRRAFKDILIDYCWRGGSERYPRSSFSKYSLAHTPLRQAMSNRV 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	37/205 (18%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	57/318 (18%)
nmur-1	NP_509515.3	7tmA_NTSR-like	52..352	CDD:320110	63/342 (18%)
		TM helix 1	52..79	CDD:320110	6/23 (26%)
		TM helix 2	86..112	CDD:320110	8/25 (32%)
		TM helix 3	125..155	CDD:320110	6/29 (21%)
		TM helix 4	168..190	CDD:320110	8/36 (22%)
		TM helix 5	230..259	CDD:320110	6/36 (17%)
		TM helix 6	276..306	CDD:320110	7/30 (23%)
		TM helix 7	320..345	CDD:320110	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910