DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and egl-6

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001257033.1	Gene:	egl-6 / 183513	WormBaseID:	WBGene00001175	Length:	395	Species:	Caenorhabditis elegans

Alignment Length:	411	Identity:	89/411 - (21%)
Similarity:	155/411 - (37%)	Gaps:	107/411 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 ELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASM 103
            |::||   ..:.:.|.....||..|||..|:| :|...|..:..|::|..|:......:.:|...
Worm    34 EIHIP---LSISICIFGAASNVFNIIVLTRKR-MRTPINILLTGLSIAQWLLATNYFLYLLLEYY 94

  Fly   104 GLPRNLHACL-------------FTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNV-RTR 154
                 .:.|:             |.|:|..|..||:....:.|:|.||.|:.:|:..:|.: :.:
Worm    95 -----RYQCVQLLWSEAFTRYRFFNVNLNTVFHTIAFTTTIVVAVFRYCALKFPIQANRFIYKCQ 154

  Fly   155 TAIFIISMCWVAGTIVGFLPLF----------------------GWHADVNHNQECLFVEVMDYN 197
            .||....:.|:...|:. ||||                      |...|:::.:..|.|..:.:.
Worm   155 PAIAANVIIWIIIPIIS-LPLFFISEVKIVARDHVAYDLQCEMEGPLYDLSYQESPLLVSAVFWA 218

  Fly   198 Y-LVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHT 261
            : :||....::|...||            |..:|.:.::.......:|:..|.:...:..:
Worm   219 FGIVFKLLPSLILSILL------------IALIRSLKSVERRRKNWKRTQGANICTNSERK---- 267

  Fly   262 GTMLRVLGAARKRDV--KATQNLSIIVLFFMICWIPLYTIN-CIKAFCPDC---YVHPKLTLFCI 320
                    |.||...  :.|:.|.||:|..::..:|:..:| |:..:..:.   |..|...|. .
Worm   268 --------AKRKLTTRPRTTRMLVIILLLCVMVELPMGILNLCVAIYGEEFGNRYYDPVGNLM-E 323

  Fly   321 ILSHLNSAVNPVLYA----YHLKDFRAAL-----KNLLLKMMGVDIDQQAEAIHRFSVASQHRLQ 376
            :|:.|.|:|:.|||.    .:|..|||..     ||.|            ....|   :..||..
Worm   324 MLTLLYSSVSFVLYCTMSNEYLSTFRALFFPWTRKNSL------------RGTRR---SWNHRHD 373

  Fly   377 SMDSNMRS-----TQPRLYVG 392
            ....:.|:     |.|..|||
Worm   374 DETKSPRTFLINRTAPSSYVG 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	45/204 (22%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	67/318 (21%)
egl-6	NP_001257033.1	7tmA_FMRFamide_R-like	35..348	CDD:320109	73/347 (21%)
		TM helix 1	35..61	CDD:320109	8/28 (29%)
		TM helix 2	67..92	CDD:320109	4/24 (17%)
		TM helix 3	111..141	CDD:320109	11/29 (38%)
		TM helix 4	154..174	CDD:320109	5/20 (25%)
		TM helix 5	212..237	CDD:320109	6/36 (17%)
		TM helix 6	273..303	CDD:320109	7/29 (24%)
		TM helix 7	316..341	CDD:320109	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910