DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and srw-117

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_503812.1	Gene:	srw-117 / 183444	WormBaseID:	WBGene00005864	Length:	372	Species:	Caenorhabditis elegans

Alignment Length:	336	Identity:	62/336 - (18%)
Similarity:	118/336 - (35%)	Gaps:	134/336 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SFEGPLLPLHAATTSKDAKDSDSPSSELNIPY--------------TVFEVLVAIVSIIGNVLVI 63
            :||...:|...:..|..::.|.| |..:||.:              .:....||:..|..|...|
Worm    26 NFEKNFIPFSYSFQSYSSEISVS-SILINIVHVFILTRKPMRTSSINILMAAVALFDIFTNFQQI 89

  Fly    64 -IVFRRERKL--------------------------RRRTNYYIVSLA-MADLLVGALGIPF-AI 99
             |:|.|...:                          ||.:.::|||:| |..|:|..   |. :.
Worm    90 EIIFERNTSIFFECFPTDTYGVILTRAIFDIVNDYSRRCSTWFIVSIAFMRTLMVRN---PLHST 151

  Fly   100 LASMGLPRNLHACLFTVSLLVV--LCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIIS- 161
            ..|:|.|        ..|::|:  :|..|:    .:|:.:::              .|..|:::
Worm   152 YQSLGNP--------NASVIVISGVCAASL----PISIFKFF--------------ETQFFVVTE 190

  Fly   162 ---MCWVAGTIVGFLPLFGWHADVNHNQECLFVE----VMDYNYLVFLYFATIITPALLMLAFYT 219
               :|.:.||.        :.|.::|    .|::    :..| :.:|..|.:.|.|.||:
Worm   191 SLYVCALQGTY--------YLAAMSH----FFMKNNGFIAKY-FSLFNSFVSDIIPCLLL----- 237

  Fly   220 HIYRVIIKQVRQIVTMNPASDL--SRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNL 282
                       .|||:....||  :.:..|.:|.|                  :.|.:.::...|
Worm   238 -----------PIVTVLLVMDLWKTAKKRANIVSV------------------SNKNNFRSKTGL 273

  Fly   283 --SIIVLFFMI 291
              .:.::||::
Worm   274 VFCVTIMFFLV 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	40/206 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	50/277 (18%)
srw-117	NP_503812.1	7TM_GPCR_Srw	53..348	CDD:370978	55/308 (18%)
		TM helix 2	71..93	CDD:320109	6/21 (29%)
		TM helix 3	114..138	CDD:320109	5/23 (22%)
		TM helix 4	163..179	CDD:320109	4/19 (21%)
		TM helix 5	219..242	CDD:320109	9/39 (23%)
		TM helix 6	271..294	CDD:320109	3/14 (21%)
		TM helix 7	309..334	CDD:320109
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910