DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and srw-118

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_503811.1	Gene:	srw-118 / 183443	WormBaseID:	WBGene00005865	Length:	378	Species:	Caenorhabditis elegans

Alignment Length:	368	Identity:	74/368 - (20%)
Similarity:	138/368 - (37%)	Gaps:	105/368 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLPLHAATTSKDAKDSDSPSSELNIPYTVFEVL-----VAIVSIIGNVLVIIVFRRERKLRRRTN 77
            ||.|:.|........|.....|:.:|:: |.:|     :::.||:.|::...:..|:.......|
Worm     8 LLWLYYAGIRNSTAKSLCEFEEIFVPFS-FHILSYSSEISVSSILINIVHFFILTRKSMRTSSIN 71

  Fly    78 YYIVSLAMADLLVGALGI-------PFAILA----SMGLPRNLHACLFTVSLLVVLCTISIFC-- 129
            ..:.::|:.|:....:.|       .|...:    :.|...|.|       ||.:|...|..|
Worm    72 ILMAAVALFDIFTSLIEIQILFERYSFIFFSCFPETYGKVLNRH-------LLHLLKDYSRRCST 129

  Fly   130 --LVAVSVDRYWAILYPMA--YSRNVRTRTAIFIISMCWVAGTIVGFLPLF-------------G 177
              :|.:::.|...|..||:  |......:.::|:|     ||.....||:.             .
Worm   130 WLMVFIALIRTLMIRNPMSTTYESLGNPKASLFVI-----AGICTTSLPISMFKFFEVQFEKSPS 189

  Fly   178 WH----------ADVNHNQECLFVEVMDYNYLVFLY--FATIITPAL--LMLAFYTHIYRVII-- 226
            :|          |.::|    .|::  ::.:|...|  |.:|::..:  ::|.|.|.:..:.:
Worm   190 YHTCAPKGTYYIATMSH----FFMK--NHGFLAKYYNLFNSIVSDIVPCILLPFVTLLLVMDLWK 248

  Fly   227 --KQVRQIVTMNPASDLSRRSSAAVVQVTTP--------GRG-GHTGTMLRVLGAARKRDVKATQ 280
              |:...|:::: .|::||..:..|..||..        |.. |.:.....|||..|
Worm   249 TAKKRPNIISVS-KSNISRSKTGLVFCVTITFFIVEFPYGLSIGFSWMFHNVLGLHR-------- 304

  Fly   281 NLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILS 323
                ||.:|...:..|.|:|.    |....|       |::||
Worm   305 ----IVAYFGHIFSMLITLNT----CTHMIV-------CLLLS 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	39/211 (18%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	63/323 (20%)
srw-118	NP_503811.1	7TM_GPCR_Srw	53..346	CDD:370978	63/322 (20%)
		TM helix 2	71..93	CDD:320109	4/21 (19%)
		TM helix 3	115..137	CDD:320109	7/28 (25%)
		TM helix 4	162..178	CDD:320109	6/20 (30%)
		TM helix 5	217..240	CDD:320109	5/22 (23%)
		TM helix 6	266..291	CDD:320109	5/24 (21%)
		TM helix 7	307..332	CDD:320109	7/35 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910