DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and srw-124

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_503810.2	Gene:	srw-124 / 183440	WormBaseID:	WBGene00005871	Length:	368	Species:	Caenorhabditis elegans

Alignment Length:	275	Identity:	50/275 - (18%)
Similarity:	106/275 - (38%)	Gaps:	62/275 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGI-----PFAILASMGL 105
            |:|  |:|:||:.|:|.:.:..|:.......|..:.::|:.|:....:.|     .::.|.....
Worm    42 VYE--VSILSILINILHLFILTRKSMRTSSINILMAAVALFDIFASLVHIQLFLEQYSYLIFKCF 104

  Fly   106 PRNLHACLFTVSLLVVLCTISIFC----LVAVSVDRYWAILYPMAYSRNV--RTRTAIFIISMCW 164
            |.:.:..:.|.:||:|:...|..|    :|.:::.|...|..|::....:  :.:.::.:|:...
Worm   105 PTDTYGLVLTRTLLIVVKDFSRRCSTWLIVFIALIRTLIIRNPLSPKHILLGKPKASLIVIAGIC 169

  Fly   165 VAGTIVGFLPLFGWHADVNHNQECLFVEVMDY------NYLVFLYFATIITPALLM-----LAFY 218
            .|...:.....|        ..:.:||.:..:      :|    ||  |.:..|.:     ||.|
Worm   170 AANLPISIFKFF--------EIQFVFVTISKHHCAPEGSY----YF--IASSELFLRDNGFLAKY 220

  Fly   219 THIYRVIIKQ-----VRQIVTMNPASDL--SRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDV 276
            .:.:...:..     :..|||.....||  :|:...|.:........|.||.:
Worm   221 FNFFNSFMSDMIPCILLPIVTCLLVMDLLKTRKKCRARISAKNNNSRGKTGLV------------ 273

  Fly   277 KATQNLSIIVLFFMI 291
                 ..:.::||::
Worm   274 -----FCVAIMFFIV 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	35/189 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	44/263 (17%)
srw-124	NP_503810.2	7TM_GPCR_Srw	41..347	CDD:370978	50/275 (18%)
		TM helix 2	71..93	CDD:320109	4/21 (19%)
		TM helix 3	116..138	CDD:320109	6/21 (29%)
		TM helix 4	163..179	CDD:320109	2/15 (13%)
		TM helix 5	219..242	CDD:320109	3/22 (14%)
		TM helix 6	267..293	CDD:320109	5/34 (15%)
		TM helix 7	308..333	CDD:320109
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910