DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and dmsr-8

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_505697.3	Gene:	dmsr-8 / 183225	WormBaseID:	WBGene00007951	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	447	Identity:	94/447 - (21%)
Similarity:	146/447 - (32%)	Gaps:	170/447 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPR 107
            ||.  .|::.:.....|::.:||..|. .:|...|..:.::|:.|:||
Worm    32 PYV--SVILCLAGTAMNIVTVIVLTRP-SMRSAVNSLLCAIALCDILV----------------- 76

  Fly   108 NLHACLFTVSLLVVLCTISIFCLVA------VSVDRYWAILYPMAYSRNVRTRTAIFIISMCWV- 165
                      :..||..::.|.|.|      ...:.|||  |.:.|....   |.||..:..|:
Worm    77 ----------MTSVLVFVTHFLLFAGYRCDPTDYNIYWA--YFLYYHSQA---TVIFHATSIWLT 126

  Fly   166 -------------AGTIVGFLPLFGWHADVNHNQECL-----FVEVMDYNYLVFLYFATIITPA- 211
                         |.::.|        ..|.:...|:     |:.|...|....|.|..|.|||
Worm   127 VLLAQIRVFSIRRATSVAG--------ESVTNQMTCIIAVTTFIVVCLLNVPNMLTFEIIETPAS 183

  Fly   212 ---------------------------LLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAV 249
                                       ||.:||:|:  .|:.|.|..:        |...|..|:
Worm   184 LWLQCKANETAEDDMLVYLVAPSDHCGLLNIAFWTN--GVLFKVVPCL--------LLTFSIVAL 238

  Fly   250 VQVTTPGRGGHTGTMLRVLGAARK------------RDVKATQNLSIIVLFFMICWIP---LYTI 299
            |.:            :|.:|..||            || ..|..|..::..|:...:|   |:..
Worm   239 VSI------------IRDVGKRRKQLAQVMNKKRMPRD-HTTPMLVAVLSIFLFAELPQGVLHVF 290

  Fly   300 NCI---KAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLL----------- 350
            |.|   :.|....|:|  |.....:||.||||||.::|....:.|||....:.|
Worm   291 NAIFTKETFYDKIYIH--LGDVMDVLSLLNSAVNFIIYCAMSRKFRAVFIQIFLTCLPQKIIRKY 353

  Fly   351 ---KMMGVDI------------DQQAEAIHRFSVASQHRLQSMDSNMRSTQPRLYVG 392
               ..:.|::            :|.|...||.|.:|     .:....|...||:|.|
Worm   354 AMEAFLDVEVSRMRPTADMTKSEQLALTSHRVSASS-----VLLPISRPDPPRMYSG 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	41/220 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	74/346 (21%)
dmsr-8	NP_505697.3	7tmA_FMRFamide_R-like	30..337	CDD:320109	81/372 (22%)
		TM helix 1	31..55	CDD:320109	6/24 (25%)
		TM helix 2	63..85	CDD:320109	7/48 (15%)
		TM helix 3	109..131	CDD:320109	5/24 (21%)
		TM helix 4	155..171	CDD:320109	3/15 (20%)
		TM helix 5	213..236	CDD:320109	8/32 (25%)
		TM helix 6	264..289	CDD:320109	6/25 (24%)
		TM helix 7	305..330	CDD:320109	11/26 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910