DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and frpr-3

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_505004.1	Gene:	frpr-3 / 182942	WormBaseID:	WBGene00016149	Length:	360	Species:	Caenorhabditis elegans

Alignment Length:	404	Identity:	87/404 - (21%)
Similarity:	154/404 - (38%)	Gaps:	90/404 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGL----PRNL 109
            ||:....|:.|.:...::.|:...::..|..:.:|:|:||.|..|.||  :.||..|    |..:
Worm    14 VLMCFGGILTNFISFYIYTRKTFRKKSINVLLAALSMSDLCVCVLAIP--VFASTQLQQVIPPTI 76

  Fly   110 HACL--FTVSLLVVLCTISIFCLVAVSVDRYWAILYP-MAYSRNVRTRTAIFIISMCWVAGTIVG 171
            .|.:  :...:.::..::|::.||::::|||.|:.:| |..:...|.|..|.:       |.:|.
Worm    77 TAMIMVYLYPVTIMFQSVSVWLLVSITIDRYLAVCHPFMVNTYCTRNRALITV-------GVVVI 134

  Fly   172 FLPLFG----WH-------ADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVI 225
            |...:.    |.       |..|...|.|.|..:..|....|::..:.| .:...||...:..|:
Worm   135 FSVAYNLIRIWEYTINFDVAPENRTIEDLVVPKLRANPHFLLWYQNVAT-LVSQFAFPLTVLCVL 198

  Fly   226 IKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFM 290
            ..||.:  |:..||:..|...|:|                       ||:....:.:.::||.|:
Worm   199 NIQVAR--TIIEASEQRRELVASV-----------------------KREHSTAKMMIMVVLVFL 238

  Fly   291 ICWIPLYTINC------------IKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRA 343
            :|:|..:.:|.            |..|..|         ...:|..:||....|.|..:...||.
Worm   239 VCYIFSFILNIWEILDKETFGGDIGWFMND---------INNVLIVVNSTSAIVFYYKYSTRFRN 294

  Fly   344 ALKNLLLKMMGVDIDQQAEAIHRFSVASQHRLQSMDSNMRSTQPRLYVGEYSPIWLRQQQEALKN 408
            ..:.|             ..|..::..|:..:...::....|....|  :.|.|.:|.....|.:
Worm   295 QARTL-------------PGIRWYASMSKFNVYDTEATSNRTMVTRY--KESMISIRGTSTRLSS 344

  Fly   409 S-QLLPKCGVVSPC 421
            | .||.|.....||
Worm   345 SHNLLYKPSYSKPC 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	43/185 (23%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	66/305 (22%)
frpr-3	NP_505004.1	7tmA_FMRFamide_R-like	12..294	CDD:320109	71/323 (22%)
		TM helix 1	12..34	CDD:320109	4/19 (21%)
		TM helix 2	41..66	CDD:320109	10/26 (38%)
		TM helix 3	81..111	CDD:320109	7/29 (24%)
		TM helix 4	123..143	CDD:320109	5/26 (19%)
		TM helix 5	176..201	CDD:320109	5/25 (20%)
		TM helix 6	221..251	CDD:320109	8/29 (28%)
		TM helix 7	264..289	CDD:320109	7/33 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910