DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and B0334.6

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_496459.2	Gene:	B0334.6 / 181927	WormBaseID:	WBGene00007146	Length:	394	Species:	Caenorhabditis elegans

Alignment Length:	388	Identity:	83/388 - (21%)
Similarity:	156/388 - (40%)	Gaps:	115/388 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LVAIVSIIGNVLVIIVFRRERKLRRRTNY-YIVSLAMADLLVGALGIPFAILASMGL-PRNLHAC 112
            ::|::.:..|:|.:.|....:..||..:: .:::||:.|.|       |.|.|::.: |.::.:.
Worm    51 VIALIGLACNLLNMAVLTSNKTARRIPSWNLLIALAVCDSL-------FLIFATLDVTPLSIPSL 108

  Fly   113 LFTVS-------LLVVLCTI-------SIFCLVAVSVDRYWAILYPM-----AYSRNVRT--RTA 156
            .|:.|       :::.:.|:       |:..:||.:::||..::.|:     ..|||.:.  .||
Worm   109 AFSTSFNHFYSRIVLYIRTLASTFYKSSVLIVVAFNIERYLCVVCPLNSHRWCTSRNSKNAIATA 173

  Fly   157 I---FIISMCW--VAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFLYFATI--------- 207
            |   |:.|:.|  ...||..|        :.|.|| ..:|.:|..|..:.:|:.|:
Worm   174 IVLSFLCSIQWPLAYDTIRCF--------ESNSNQ-YYYVILMSTNRALQIYYRTMDYVSLFAFN 229

  Fly   208 ITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAAR 272
            :.|.:.:|    ::...||..:|::|..:.......:.|..::|     ...|....:|.
Worm   230 VLPIIGLL----YMNSRIIFTLRRVVDEDSRKYEETKLSDGLIQ-----HDAHNNRTMRA----- 280

  Fly   273 KRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCP-----DCY--VHPKLTLFCII---LSHLNS 327
                    |..:..:.||:.:       |:....|     |.|  .|||..|:..:   |..||:
Worm   281 --------NAMLFAVVFMLFF-------CVGPQAPARILFDMYGQYHPKAILYVCLSQQLVFLNA 330

  Fly   328 AVNPVLYAYHLKDFRA----ALKNLLLKMMGVDIDQQAEAIHRFSVASQHRLQSMDSNMRSTQ 386
            ::|..||....|.:|.    .||..|.|:.|||        |.|.:           |::.|:
Worm   331 SLNFCLYCVVSKRYRTLMKQTLKKFLHKLEGVD--------HPFQI-----------NLKQTK 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	45/204 (22%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	67/322 (21%)
B0334.6	NP_496459.2	7tmA_FMRFamide_R-like	43..348	CDD:320109	72/341 (21%)
		TM helix 1	45..69	CDD:320109	4/17 (24%)
		TM helix 2	79..101	CDD:320109	7/28 (25%)
		TM helix 3	123..145	CDD:320109	4/21 (19%)
		TM helix 4	168..184	CDD:320109	5/15 (33%)
		TM helix 5	218..241	CDD:320109	3/26 (12%)
		TM helix 6	278..303	CDD:320109	6/44 (14%)
		TM helix 7	316..341	CDD:320109	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910