DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and ser-1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001024728.1	Gene:	ser-1 / 181716	WormBaseID:	WBGene00004776	Length:	683	Species:	Caenorhabditis elegans

Alignment Length:	639	Identity:	141/639 - (22%)
Similarity:	239/639 - (37%)	Gaps:	191/639 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASM--GL-PRNLHA 111
            ::.::.:|||.||.:....:|:|...|||::.|||:|||||..:.:|.:|:..:  |: ..::..
Worm    64 VLCLIGLIGNFLVCVAIATDRRLHNVTNYFLFSLALADLLVCCIVMPLSIVVEVRHGVWTWSVSM 128

  Fly   112 CLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFI-ISMCWVAGTIVGF-LP 174
            ||..|...|.||:.||..:..:|:|||..|..|:. :|| |::|.||| |::.||...:|.. :.
Worm   129 CLLYVYSDVFLCSASIVHMSVISLDRYLGISQPLR-TRN-RSKTLIFIKIAIVWVVTLLVSCPIA 191

  Fly   175 LFGWH--ADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNP 237
            :...|  |::..|.:|:   :....|:::....|.:.|..:|...|....:::.||..  :....
Worm   192 VLAMHDTANILRNNQCM---IFSRYYIIYGSTMTFLIPLCIMGVTYAKTTQLLNKQAS--ILSQK 251

  Fly   238 ASD-----------------LSRRSSAAVVQVTTPGR--GGHTGTMLRV-----------LGAAR 272
            |.|                 .:|..||.|......|:  |.|..||..:           ||.:|
Worm   252 AGDKFNGNGLRRTMPHRKLGYARTYSATVNGTIANGKAIGAHGRTMSSISNIANGETADRLGTSR 316

  Fly   273 ------------------------------------------------KRDVKATQNLSIIVLFF 289
                                                            ..:.|||:.|:::...|
Worm   317 PSINTNGHKQLQKASTINKWKSRTSNLVTNFANKVGRRSSLQTATQDLANEHKATRVLAVVFACF 381

  Fly   290 MICWIPLYTINCIKAF------CPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNL 348
            .|||.|.:.||.:..|      .||...    ::| :.|.:::|.:||::|....|.||.|...:
Worm   382 FICWTPFFFINFLIGFGGENVQIPDWVA----SIF-LWLGYVSSTINPIIYTVFNKRFRQAFVRI 441

  Fly   349 LLKMMGVDIDQQAEAIHRFSVASQHRLQSMDSNMRST-QPRLYVGEYSPIWLRQQQEALKNSQLL 412
            |          :.:..|  .:...|::.|  .|..:| .|..|.
Worm   442 L----------RCQCFH--PLRDSHQMYS--RNFTTTIVPDTYT--------------------- 471

  Fly   413 PKCGVVSPCFNNINQTVAAVASVTTDLEREMWNIVEASSGAELGETSYEFPSPAPGSQRSSERNS 477
                    |..:..:...:|  :|.|..|              ...|.|.|.|:......||...
Worm   472 --------CSRSNQERTTSV--ITRDETR--------------SARSSERPEPSRARSEISEEPV 512

  Fly   478 SSTVPPAPPAPAKPSVP-----SASYDNHNYSFSQDEDEDDDDLEFEDVFVPASSVP----NPVQ 533
            :.|.........|.|:|     |:|.|:...:.:...||:...|      :|.|:||    |..:
Worm   513 ARTNGKLTSEKKKISLPSFPRVSSSRDSRATTEASTTDEETKPL------IPKSTVPATVINIPE 571

  Fly   534 PGIDPVELRRSLALVMREKLRSDDTDSRPMGNNQDLPIDEQSRERPLSTQTSPT 587
            ..|:|:  ::||..::...| .|:|          :|...|...:..:..||.|
Worm   572 QLINPI--KKSLTTIINMPL-LDET----------IPEKAQVHHKSQTLLTSST 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	55/174 (32%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	89/366 (24%)
ser-1	NP_001024728.1	7tmA_5-HT2	56..438	CDD:320180	94/385 (24%)
		TM helix 1	57..83	CDD:320180	5/18 (28%)
		TM helix 2	90..116	CDD:320180	13/25 (52%)
		TM helix 3	129..159	CDD:320180	12/29 (41%)
		TM helix 4	170..193	CDD:320180	8/22 (36%)
		TM helix 5	211..240	CDD:320180	5/28 (18%)
		TM helix 6	365..395	CDD:320180	11/29 (38%)
		TM helix 7	406..431	CDD:320180	7/29 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910