DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and sprr-2

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_510455.2	Gene:	sprr-2 / 181575	WormBaseID:	WBGene00009629	Length:	451	Species:	Caenorhabditis elegans

Alignment Length:	411	Identity:	93/411 - (22%)
Similarity:	155/411 - (37%)	Gaps:	117/411 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLPLHAATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVS 82
            ||||    |..|       :.|:.:...:|.:|| :.::..|..|.:|..::..: ..||..:..
Worm    47 LLPL----TQFD-------NLEIVVYGQIFPILV-LFAVFANAAVALVLSKKHMI-TPTNVVLKY 98

  Fly    83 LAMADLLVGALGIPFAI-LASMGLPRNLHA-----CLFTV----SLLVVLCTISIFCLVAVSVDR 137
            :|:|:||||.:.:|:.: ..|||..:..|.     |....    :...|...|:::..|.::..|
Worm    99 MAIAELLVGLVPLPWTLFFFSMGNIKETHRLELWWCYLQKYSMDAFPPVFHMIAMWLTVLLAAQR 163

  Fly   138 YWAILYPMAYSR------NVRTRTAIFIISMCWVAGTIVGFL------------PLFGW---HAD 181
            |.:|.:|: :||      |||..|.|.         |:..||            .:.||   |.:
Worm   164 YVSISHPL-HSRSACNVKNVRLATMII---------TVTSFLCGLPKSFDYEYETVHGWIYSHGN 218

  Fly   182 VNHNQECLFVEV-----MDYNYLVFLYFAT-----IITPALLMLAFYTHIYRVIIKQVRQIVTMN 236
            ..:...|:.:..     |.......:||.|     ||.|:.|::.    :..::||.:|:
Worm   219 WTYASSCVMMPTAILTNMGQTVYFNIYFWTRALGFIILPSFLLVL----LNGLLIKGIRR----- 274

  Fly   237 PASDLSRRSSAAVVQVTTPGRGGHTGTMLRVL------GAARKRDVKATQNLSI-IVLFFMICWI 294
                ..||.                   ||:|      .|||:||..:|..:.: ||..|:|..:
Worm   275 ----AQRRK-------------------LRLLREKRSEEAARQRDSNSTSLMLVAIVSIFLIVNL 316

  Fly   295 PLYTINCIKAFCPDCYVH-PKL-----TLFCIILSHLNSAVNPV---LYAYHLKDFRAALKNLLL 350
            |......:...|....:. |.|     .:|.|..:.:..|..|:   :|.:....||...|  ||
Worm   317 PQAIFMGLLCVCETFTIKIPILEGTFPAVFLIASNMIVIATYPINFGIYCFMSSSFRQTFK--LL 379

  Fly   351 KMMGVDIDQQAEAIHRFSVAS 371
            ...|.   .|.:...|...||
Worm   380 FCPGA---SQLQCERRIEAAS 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	46/208 (22%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	72/332 (22%)
sprr-2	NP_510455.2	7tmA_FMRFamide_R-like	59..376	CDD:410630	78/360 (22%)
		TM helix 1	61..85	CDD:410630	6/24 (25%)
		TM helix 2	93..115	CDD:410630	8/21 (38%)
		TM helix 3	139..161	CDD:410630	3/21 (14%)
		TM helix 4	184..200	CDD:410630	5/24 (21%)
		TM helix 5	243..266	CDD:410630	7/26 (27%)
		TM helix 6	301..323	CDD:410630	5/21 (24%)
		TM helix 7	344..369	CDD:410630	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910