Protein Alignment AdoR and DRD4

DIOPT Version :10

• Sequence 1: NP_651772.1
• Gene: AdoR / 43583
• FlyBaseID: FBgn0039747
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_000788.2
• Gene: DRD4 / 1815
• HGNCID: 3025
• Length: 419
• Species: Homo sapiens
• Alignment Length: 384
• Identity: 97/384 - (25%)
• Similarity: 154/384 - (40%)
• Gaps: 93/384 - (24%)

  Fly    49 VLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMG------LPR 107
            ||:....:.||.||.:....||.|:..||.:|||||.||||:..|.:|..:.:.:.      .||
Human    42 VLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPR 106

  Fly   108 NLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGF 172
               .|...:::.|:|||.|||.|.|:||||:.|:..|:.|:|...:|..:.:|...|:....|..
Human   107 ---LCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAA 168

  Fly   173 LPLFGWHADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIK-QVRQIVTMN 236
            ..|.|.: || ..::.....:.|.:|:|:....:...|..|||..|...:|.:.: :|.:...::
Human   169 PVLCGLN-DV-RGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLH 231

  Fly   237 ---------------------------------PASDLSR------------------------- 243
                                             ||..|.|
Human   232 GRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAP 296

  Fly   244 ------------------RSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFM 290
                              ...||.:...||.:     |..|.......|:.||.:.|.::|..|:
Human   297 PAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQ-----TRRRRRAKITGRERKAMRVLPVVVGAFL 356

  Fly   291 ICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLL 349
            :||.|.:.::..:|.||.|.|.|:|......|.::|||:|||:|.....:||...:..|
Human   357 LCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKAL 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tmA_Adenosine_R	42..345	CDD:341316	96/378 (25%)
		TM helix 1	43..69	CDD:341316	6/19 (32%)
		TM helix 2	76..103	CDD:341316	13/26 (50%)
		TM helix 3	112..142	CDD:341316	15/29 (52%)
		TM helix 4	156..174	CDD:341316	3/17 (18%)
		TM helix 5	196..225	CDD:341316	8/28 (29%)
		TM helix 6	273..303	CDD:341316	9/29 (31%)
		TM helix 7	313..338	CDD:341316	10/24 (42%)
DRD4	NP_000788.2	7tmA_D4_dopamine_R	38..411	CDD:320434	96/378 (25%)
		TM helix 1	38..62	CDD:320434	6/19 (32%)
		TM helix 2	69..95	CDD:320434	13/25 (52%)
		TM helix 3	108..138	CDD:320434	15/29 (52%)
		TM helix 4	150..173	CDD:320434	5/22 (23%)
		TM helix 5	189..218	CDD:320434	8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..264		0/33 (0%)
		4 X 16 AA approximate tandem repeats of [PA]-A-P-G-L-P-[PQR]-[DG]-P-C-G-P-D-C-A-P	249..312		4/62 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..336		6/23 (26%)
		TM helix 6	339..369	CDD:320434	9/29 (31%)
		TM helix 7	379..404	CDD:320434	10/24 (42%)