DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and npr-1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_508816.1	Gene:	npr-1 / 180752	WormBaseID:	WBGene00003807	Length:	457	Species:	Caenorhabditis elegans

Alignment Length:	443	Identity:	95/443 - (21%)
Similarity:	174/443 - (39%)	Gaps:	94/443 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PSSELN--IPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFA 98
            ||..:.  :|:....:.:..:.:.|||.:|.|....:.|....|.:|::||.:|.::..|.:|..
Worm    19 PSQSIYAIVPFLTVYLFLFFLGLFGNVTLIYVTCSHKALLSVQNIFILNLAASDCMMCILSLPIT 83

  Fly    99 ILASM-------GLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTA 156
            .:.::       .|..:|..|:..:|:.|  ||   |.|.|:::|||..::.|  :|..:..|.|
Worm    84 PITNVYKNWYFGNLLCHLIPCIQGISIFV--CT---FSLGAIALDRYILVVRP--HSTPLSQRGA 141

  Fly   157 IFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDY-------------NYLVFLYFATII 208
            .....:.|:...:|.....|.... :.:.:|    .:..|             .|.:.:..|..:
Worm   142 FLTTVLLWILSFVVTLPYAFNMQM-IEYTEE----RICGYFCTEKWESAKSRRAYTMIVMLAQFV 201

  Fly   209 TPALLMLAFYTHIYRVIIK----QVRQIVTMNPASDLSRRSSAAVVQVTTPGRG--GHTGTMLRV 267
            .|..:|...|.:|..|:.|    ::|::|         .|:||.......|..|  .:...:...
Worm   202 VPFAVMAFCYANIVSVLSKRAQTKIRKMV---------ERTSALESSCAFPSHGLEQYENELNEF 257

  Fly   268 LGAARK-------RDVKATQNLSIIVLFFMICWIPLYTINCI----------KAFCPDCY-VHPK 314
            |....|       ::.:.|..|..:|::|.|.|:|...|:.|          :.:..|.| :...
Worm   258 LDKQEKEKQRVVLQNRRTTSILVTMVVWFGITWLPHNVISLIIEYDDTQSFFRLYGRDDYDISYL 322

  Fly   315 LTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVASQ---HRLQ 376
            |.||...::..|:.:||||||:....||    .|::|....|..:....|::.||...   |..:
Worm   323 LNLFTHSIAMSNNVLNPVLYAWLNPSFR----QLVIKTYFGDRRKSDRIINQTSVYKTKIVHDTK 383

  Fly   377 SMDSNMRSTQPRLYVGEYSPIWLRQQQEALKNSQLLPKCGVVSPCFNNINQTV 429
            .::.       |..:|...      ..||||..:|       :.|..|::..|
Worm   384 HLNG-------RAKIGGGG------SHEALKEREL-------NSCSENLSYHV 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	40/187 (21%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	70/319 (22%)
npr-1	NP_508816.1	7tmA_NPYR-like	27..351	CDD:320331	76/348 (22%)
		TM helix 1	29..53	CDD:320331	5/23 (22%)
		TM helix 2	62..84	CDD:320331	7/21 (33%)
		TM helix 3	100..122	CDD:320331	9/26 (35%)
		TM helix 4	143..159	CDD:320331	2/15 (13%)
		TM helix 5	189..212	CDD:320331	4/22 (18%)
		TM helix 6	273..298	CDD:320331	8/24 (33%)
		TM helix 7	321..346	CDD:320331	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910