DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and dop-1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001370620.1	Gene:	dop-1 / 180714	WormBaseID:	WBGene00001052	Length:	460	Species:	Caenorhabditis elegans

Alignment Length:	451	Identity:	116/451 - (25%)
Similarity:	190/451 - (42%)	Gaps:	111/451 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VFEVLVAIVSIIGNVLVIIVFRRERKLRRR-TNYYIVSLAMADLLVGALGIPFAILAS-MGL-PR 107
            :|.||: |:::.||:||......:|.||:: .|.::||||::||||..|.:.||.:.. :|. |.
Worm    11 LFSVLI-ILALFGNLLVCAAILWDRSLRKQPENLFLVSLAVSDLLVSVLVMLFAAVNDILGYWPF 74

  Fly   108 NLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGF 172
            ....|.|.:|..:..||.||..|.|:|:||||.|..||.|.|....|...::|.:.|:....:|.
Worm    75 GQFYCQFWISFDITTCTASILNLCAISLDRYWHISRPMVYIRYCNRRRINYVIVLVWLISAGIGA 139

  Fly   173 LPL---FGWHADVNHNQECLFVEV-MDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIV 233
            .||   ||....:|:.......|: :...|.:.....:...||::|:..||.:|....|.||.|.
Worm   140 APLGFGFGSKVTINNLTGLPVCEMRLPLPYAIGSSMVSFFLPAMVMVILYTKLYLYARKHVRSIK 204

  Fly   234 TM----------------------------------NPASD-----LSR---RSSAAVVQVTTPG 256
            |.                                  :||::     :||   |.|.......||.
Worm   205 TQLQQATSFLIMQLASEKIREVTAATLKGEALLPPDSPATERTTMTVSRHYSRRSTTTTTTATPR 269

  Fly   257 RGG-HTGTMLRV-----------------------------LGAARKR----DVKATQNLSIIVL 287
            ||. .|.:..:|                             ..||..|    |.||...|.:|:.
Worm   270 RGDKKTSSQNKVESIRTSIFSKLNFLCPTRFKNQRSPQDPHTPAAHNRSNISDQKARLTLGVIMG 334

  Fly   288 FFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKM 352
            .|::||:|.:|:|.::|:.|:.: ..|..:....|.:.||:.||::|:...:|||.|.|.:::::
Worm   335 TFLVCWLPFFTVNILRAWLPEIF-SSKTIMAVTWLGYANSSANPLIYSIFNRDFRRAFKKIIVRV 398

  Fly   353 MGV-----DID--------------------QQAEAIH-RFSVASQHRLQSMDSNMRSTQP 387
            .|.     |::                    :.:|:.| ..:.|:..||..:.:|...|.|
Worm   399 FGCCWEEPDLNKSISSRYAAPDNIERRRSCTRSSESAHDNNNDANATRLNLLSNNNEETIP 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	56/174 (32%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	96/358 (27%)
dop-1	NP_001370620.1	7tmA_Ap5-HTB1-like	7..391	CDD:320193	104/381 (27%)
		TM helix 1	8..32	CDD:320193	8/21 (38%)
		TM helix 2	42..64	CDD:320193	11/21 (52%)
		TM helix 3	80..102	CDD:320193	8/21 (38%)
		TM helix 4	125..141	CDD:320193	3/15 (20%)
		TM helix 5	167..190	CDD:320193	4/22 (18%)
		TM helix 6	326..348	CDD:320193	7/21 (33%)
		TM helix 7	359..384	CDD:320193	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910