DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and dop-6

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001359889.1	Gene:	dop-6 / 180706	WormBaseID:	WBGene00016037	Length:	692	Species:	Caenorhabditis elegans

Alignment Length:	733	Identity:	144/733 - (19%)
Similarity:	234/733 - (31%)	Gaps:	350/733 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AATTSKDAKDSDSPSSELNIPYTVFEVL--VAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAM 85
            ||..:.:.:|      ||..|...:.||  |.:|.|:||::|:......:.|:..||:.:|||||
Worm     8 AAVAAMELED------ELLQPEWAYLVLSIVPLVCILGNLMVVAAVWTTKSLQTPTNHLLVSLAM 66

  Fly    86 ADLLVGALGIPFAILASMG-----LPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPM 145
            |||:|||..:||:|..|:.     ||  |..|.|...|.|...|.||..||.:|:||..|...|.
Worm    67 ADLIVGAFVMPFSIYLSVNRLHWHLP--LFVCYFYCVLDVAASTSSIIHLVLISIDRLVAATKPA 129

  Fly   146 AYSRNVRTRTAIFI-ISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMD-----YNYLVFL-- 202
            .| :.|:.|..::: |::.|:. :|...|||     ....|....:..|::     ||.:..|
Worm   130 EY-KTVKHRKRVYLAIAITWIF-SIALSLPL-----GTGFNTRTSYFLVIEHHCGIYNPIYMLGS 187

  Fly   203 -YFATIITPALLMLAFYTHIYRVIIKQVRQI---------------------------------- 232
             .||..: |.|:|:..|.:|:..:.|::|.|
Worm   188 SIFAFYL-PCLIMIFTYGYIFYTLRKRLRAIQLQEMAGGQFLGFGADVSNITTSAIQSVIGIAPK 251

  Fly   233 ----VT----------------------------------MNPAS-------------------- 239
                :|                                  ::|:|
Worm   252 NRNMITWEKPLLKKIEETAAEHASSLNDSEREQLQTILEAVHPSSSGSQENTTIEEDPDRPPSVL 316

  Fly   240 --------------------------DLSRRSSAAVVQVTTPGR--------------------- 257
                                      ::|||.|.||..:::.||
Worm   317 LEAVTLKCEIDTSGPILELPRPTYTKNMSRRFSDAVNSISSRGRMKSVSFGTSRKRRHSHQPQGN 381

  Fly   258 --------------------------------------------------------------GGH 260
                                                                          .|.
Worm   382 REVVTSEESKKLHSLKPPLVEKRKMRRLSEMISDWERPSRSSISNMYLYARRESVYIARKKLAGL 446

  Fly   261 TGTMLRVL-------GAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLF 318
            ....|.:|       |.|.:|:.:||:.::.:::.|::||:|.:|:|.||.:        || :|
Worm   447 KDWALDLLAKLKSKQGMAIRRETRATKLVATVMVVFLVCWLPFFTLNMIKIY--------KL-IF 502

  Fly   319 CI-------------ILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVA 370
            .:             .|.:|||::|..:|:.....||.:.:.||             ...|.|
Worm   503 NVWSADLEIWFHWFTALGYLNSSLNFFIYSTINPKFRHSFRRLL-------------GFRRSS-- 552

  Fly   371 SQHRLQSMDSNMRSTQPRLYVGEYSPIWLRQQQEALKNSQLLP---------KCG------VVSP 420
                                         |:|:|   .|.:||         |||      |.||
Worm   553 -----------------------------RRQRE---KSWMLPPRDSSRGPAKCGCGFHKIVKSP 585

  Fly   421 C--------FNNINQTVAAVASVTTDLEREMWNIVEASSGAELGETSYEFPSPAPGSQRSSE--- 474
            .        .||...::.....|..::..   |.:..|:|   |.|::         :|||:
Worm   586 LRKTSSAGPMNNRKISMQKPEIVIDEISP---NRISISAG---GNTTF---------RRSSDDCI 635

  Fly   475 RNSSSTVPPAPPAPAKPS 492
            |.|||.:......|::.|
Worm   636 RRSSSEIIGGITLPSQSS 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	60/181 (33%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	97/510 (19%)
dop-6	NP_001359889.1	7tmA_amine_R-like	24..>217	CDD:320098	66/202 (33%)
		TM helix 1	25..49	CDD:320098	8/23 (35%)
		TM helix 2	58..80	CDD:320098	14/21 (67%)
		TM helix 3	97..119	CDD:320098	8/21 (38%)
		TM helix 4	142..158	CDD:320098	4/16 (25%)
		TM helix 5	181..204	CDD:320098	6/23 (26%)
		7tm_GPCRs	<464..542	CDD:391938	23/86 (27%)
		TM helix 6	466..496	CDD:341315	9/29 (31%)
		TM helix 7	513..535	CDD:341315	6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910