DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and gtr-1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_508157.1	Gene:	gtr-1 / 180427	WormBaseID:	WBGene00017779	Length:	329	Species:	Caenorhabditis elegans

Alignment Length:	384	Identity:	84/384 - (21%)
Similarity:	138/384 - (35%)	Gaps:	134/384 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TDFSFEGPLLPLHAATTSKDAKDSDSPSSEL--NIPYTVFEVLVAI-------VSIIGNVLVIIV 65
            |:|.::.|..||      .:...||.|..:|  ....|.||.:|.|       ..|..|.|||::
Worm     5 TNFDWDFPDFPL------GNYSSSDFPIEKLRHGDDETNFETIVGIAVVFSAATGIFANFLVILL 63

  Fly    66 --------FRRERKLRRRTNYYIVSLAMADLLVGAL-------------GIPFAILASMGLPRNL 109
                    ||          :::.:||:.|:|.|::             .||...|..|.|
Worm    64 SFGHVQGDFR----------FFVANLALVDILCGSVFMFMGYINVNDDHHIPSQFLYYMTL---- 114

  Fly   110 HACLFTVSLLVVLCTISIFCLVAVSVDRYWAI----LYPMAYSRNVRTRTAIFIISMCWVAGTIV 170
               .|..|...::|.|     |.:|:.|..|:    ||...:...   |:.||.|        .:
Worm   115 ---AFYGSFGTMICAI-----VPISLSRVLALSNASLYSTCFGGR---RSLIFCI--------FL 160

  Fly   171 GFLPLFGWHADVNHNQECL--FVEVMDYNYL-VFLYFATIITPALLMLAFYTH--IYRVIIKQVR 230
            .|||:            |:  .:.|::::.. |..|....||.....:||.|:  ::||:.|.::
Worm   161 DFLPV------------CILYLICVVEHDVAKVLFYIFAFITTLAYFVAFTTNYMVFRVVAKHIQ 213

  Fly   231 QIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIP 295
            .:..::..:.|......|:                            ||...:||.||   |.:|
Worm   214 VVENLHDQARLLETRQVAI----------------------------ATLAQAIIPLF---CQVP 247

  Fly   296 LY-TINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYA----YHLKDFRAALKNLL 349
            .: |::.:....     .|......||.:.|..|::|.|.|    ..:|.:|   ||.|
Worm   248 AFLTLSSVLLLS-----EPITNGHVIITTQLWLALSPFLDAVITIIVIKQYR---KNCL 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	43/202 (21%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	62/306 (20%)
gtr-1	NP_508157.1	7tm_GPCRs	44..278	CDD:333717	63/314 (20%)
		TM helix 1	44..64	CDD:320095	6/19 (32%)
		TM helix 2	73..95	CDD:320095	6/31 (19%)
		TM helix 3	110..132	CDD:320095	7/33 (21%)
		TM helix 4	155..169	CDD:320095	7/33 (21%)
		TM helix 5	181..202	CDD:320095	7/20 (35%)
		TM helix 6	228..253	CDD:320095	10/55 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24246
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100