DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and dmsr-7

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_504431.2	Gene:	dmsr-7 / 178922	WormBaseID:	WBGene00016428	Length:	429	Species:	Caenorhabditis elegans

Alignment Length:	428	Identity:	86/428 - (20%)
Similarity:	154/428 - (35%)	Gaps:	103/428 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRN----- 108
            ||:.:..|..|.:.:.|..|........|..:.::|:.|  :|.:......:....|.||
Worm    40 VLICVFGIFTNFVHVAVLSRPNMRNSAVNCILTAVAVCD--IGTMASYLIYIIHFVLRRNNSCTP 102

  Fly   109 ------LHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTA--------IFI 159
                  |...|:.|.|.:.|.|.|::..||::..|...:......|:..|.:.|        :.:
Worm   103 TFTHSWLQFLLWHVVLSITLHTTSLWLAVAMAFIRRMTLRVTALNSQWQRPKFAWKLCLGIYMVV 167

  Fly   160 ISMC----------------WVAG-TIVGFL-----PLFGW---HADVNHNQECLFVEVMDYN-Y 198
            ..:|                |..| |...|.     |::.:   ||...:|  |   .:..:| :
Worm   168 FVLCIPNMLVHEIARVEGNDWRPGKTCQKFASNYSEPVYTFMVSHAATINN--C---RLFKWNIW 227

  Fly   199 LVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGT 263
            ::.:.|..|....|:.|:|      .::.::|.       ::..||...:|     |........
Worm   228 MIGILFKIIPCILLIFLSF------GLVSKIRD-------AEKHRRKLTSV-----PSNASTDSK 274

  Fly   264 MLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKA-FCPDCYVHPKLTLF----CIILS 323
            .|:.......|   .|..|.:|:|.|:|...|...|:.:.| |..|  ||..|..:    ..:||
Worm   275 PLKKKNGTSDR---TTLMLVVILLVFLITEFPQGIISILCAIFTTD--VHRYLYFYIGDVLDLLS 334

  Fly   324 HLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVASQHRLQSMDSNMR----- 383
            .:||:||.|||......:|.....:::......:    ....|.|.....:|| :::::|
Worm   335 LVNSSVNFVLYCVMSSRYRQTFWEVIIPSWACGL----WTTRRGSPTELSQLQ-LNNSLRLGRKQ 394

  Fly   384 -----STQPRLYVGEYSPIW-----LRQQQEALKNSQL 411
                 :|:|.....||   |     :...|.:.:..||
Worm   395 SYTPLATEPEPARNEY---WRYEASVSDNQNSSREHQL 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	40/212 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	67/325 (21%)
dmsr-7	NP_504431.2	7tmA_FMRFamide_R-like	33..356	CDD:320109	73/345 (21%)
		TM helix 1	35..59	CDD:320109	5/18 (28%)
		TM helix 2	68..90	CDD:320109	4/23 (17%)
		TM helix 3	113..135	CDD:320109	8/21 (38%)
		TM helix 4	158..174	CDD:320109	1/15 (7%)
		TM helix 5	223..246	CDD:320109	5/22 (23%)
		TM helix 6	284..309	CDD:320109	9/27 (33%)
		TM helix 7	324..349	CDD:320109	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910