DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and npr-2

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_501701.2	Gene:	npr-2 / 177790	WormBaseID:	WBGene00003808	Length:	430	Species:	Caenorhabditis elegans

Alignment Length:	392	Identity:	88/392 - (22%)
Similarity:	162/392 - (41%)	Gaps:	85/392 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLPLHAATTSKDAKDS-----DSPSSELNIP-----YTVFEVLVAIVSIIGNVLVIIVFRRERKL 72
            |:.||::....:.:::     |......|.|     :::..:.:.::.|:||..|:.:..:.|:|
Worm    36 LIQLHSSQMINETEETCDRYIDKHPDMTNEPTVLVTFSLLYLHIFLLGILGNSAVLYLTMKHRQL 100

  Fly    73 RRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNLHACLF---TVSLLVVLCT-----ISIFC 129
            :...|.:|::|..:::|:....:|...:.      |::...|   .|..|:.|..     :|.|.
Worm   101 QTVQNIFILNLCASNVLMCLTSLPITFIT------NVYKQWFFSSPVCKLIPLVQGASIFVSTFS 159

  Fly   130 LVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNH---------N 185
            |.|:::|||..::.|  :.:.:.:|:|:.|..:.||...:| .:| :||:.||..         :
Worm   160 LSAIALDRYNLVVRP--HKQKLSSRSAMMIALLIWVISVVV-CMP-YGWYMDVEKLNGLCGEYCS 220

  Fly   186 QECLFVEV-MDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAV 249
            :.....|| ..|.:||      :||..|...|.....|..|..::||.|. .....||.||. .:
Worm   221 EHWPLAEVRKGYTFLV------LITQFLFPFATMAFCYYNIFSRLRQRVE-TKLKKLSERSQ-LL 277

  Fly   250 VQVTTPGRGGHTGTM--------------LRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTIN 300
            ...||.|...|..::              |.||...|    :.|..||.:||.|...|:|...:.
Worm   278 ENSTTCGTTNHIVSINAEAVQNGLENKQRLAVLAQQR----RTTTILSCMVLLFAFTWLPHNVVT 338

  Fly   301 CI-------------KAFCPD-CYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLK 351
            .:             .|...| .|:   :::...::|.|.:..||.|||:    .....|.:|:|
Worm   339 LMIEYDGFFFHSDETSATSTDHTYI---VSMTAHLISMLTNVTNPFLYAW----LNPMFKEMLIK 396

  Fly   352 MM 353
            .:
Worm   397 TL 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	44/185 (24%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	75/321 (23%)
npr-2	NP_501701.2	7tmA_NPYR-like	70..394	CDD:320331	80/352 (23%)
		TM helix 1	72..96	CDD:320331	4/23 (17%)
		TM helix 2	105..127	CDD:320331	5/21 (24%)
		TM helix 3	143..165	CDD:320331	6/21 (29%)
		TM helix 4	186..202	CDD:320331	5/17 (29%)
		TM helix 5	230..253	CDD:320331	7/28 (25%)
		TM helix 6	314..339	CDD:320331	9/28 (32%)
		TM helix 7	362..387	CDD:320331	8/31 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910