DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Htr6

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001364025.1	Gene:	Htr6 / 15565	MGIID:	1196627	Length:	440	Species:	Mus musculus

Alignment Length:	357	Identity:	92/357 - (25%)
Similarity:	165/357 - (46%)	Gaps:	26/357 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASM----GLPRNLH 110
            :|.:::...|.|:|.:...:..||..:|:::|||..:||:||.:.:|.|:|.::    .|.|.|
Mouse    35 VVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGL- 98

  Fly   111 ACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLP- 174
             ||...:..|:.|:.||..|..:|:|||..||.|:.|...:....|:.:|...|....:..|||
Mouse    99 -CLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPL 162

  Fly   175 LFGWH----ADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTM 235
            |.|||    |..:...:|..:..:.  |::.....|...|:..:...|..|.....||..|:.::
Mouse   163 LLGWHELGKARTSAPGQCRLLASLP--YVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASL 225

  Fly   236 NPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTIN 300
            ...:..:.::...:....||..|..:....|:.....::.:||:..|.|::..|.:.|:|.:..:
Mouse   226 TTGTATAGQALETLQVPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVAS 290

  Fly   301 CIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIH 365
            ..:|.| || :.|.|......|.:.||.:||::|...::||:.||...:..:       .....|
Mouse   291 IAQAVC-DC-ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCV-------HCPPEH 346

  Fly   366 RFSVASQHRLQSMDSNMRSTQPRLYVGEYSPI 397
            |.|.||    .||.::....:|.|.:.:..|:
Mouse   347 RASPAS----PSMWTSHSGARPGLSLQQVLPL 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	50/176 (28%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	76/284 (27%)
Htr6	NP_001364025.1	7tmA_5-HT6	29..333	CDD:320182	80/303 (26%)
		TM helix 1	29..53	CDD:320182	4/17 (24%)
		TM helix 2	62..84	CDD:320182	9/21 (43%)
		TM helix 3	100..122	CDD:320182	6/21 (29%)
		TM helix 4	145..161	CDD:320182	3/15 (20%)
		TM helix 5	186..209	CDD:320182	3/24 (13%)
		TM helix 6	269..291	CDD:320182	5/21 (24%)
		TM helix 7	301..326	CDD:320182	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910