Protein Alignment AdoR and Htr1f

DIOPT Version :9

• Sequence 1: NP_651772.1
• Gene: AdoR / 43583
• FlyBaseID: FBgn0039747
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_032336.1
• Gene: Htr1f / 15557
• MGIID: 99842
• Length: 366
• Species: Mus musculus
• Alignment Length: 380
• Identity: 102/380 - (26%)
• Similarity: 166/380 - (43%)
• Gaps: 81/380 - (21%)

  Fly    29 DAKDSDSPSSEL--NIPYTVFEVL----VAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMAD 87
            :|.|.:..|.||  .:|..:...|    :|:::...|.|||......|||....||.|.|||:.|
Mouse     5 NASDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTD 69

  Fly    88 LLVGALGIPFAILA------SMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMA 146
            .||..|.:||:|:.      .||..    .|...:|:.::.||.||..|.|:::|||.||...:.
Mouse    70 FLVAVLVMPFSIVYIVRESWIMGQV----LCDIWLSVDIICCTCSILHLSAIALDRYRAITDAVE 130

  Fly   147 YSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLV---FLYFATII 208
            |:|....|.|..:|::.||....:...|||..|...:.:.||    |:.::::|   :..|....
Mouse   131 YARKRTPRHAGIMITIVWVISVFISMPPLFWRHQGTSRDDEC----VIKHDHIVSTIYSTFGAFY 191

  Fly   209 TPALLMLAFYTHIYRV------------IIKQ--------------VRQIVT--------MNPAS 239
            .|.:|:|..|..|||.            :||:              ::.:.|        .:|::
Mouse   192 IPLVLILILYYKIYRAARTLYHKRQASRMIKEELNGQVFLESGEKSIKLVSTSYMLEKSLSDPST 256

  Fly   240 DLSRRSSAAVVQVTTP----------GRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWI 294
            |..|..|.    |.:|          .|...:||          |:.||...|.:|:..|:|||:
Mouse   257 DFDRIHST----VKSPRSELKHEKSWRRQKISGT----------RERKAATTLGLILGAFVICWL 307

  Fly   295 PLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLL 349
            |.:....:...|..|.:..:::.|...|.:|||.:||::|....:||:.|.:.|:
Mouse   308 PFFVKELVVNVCEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLV 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	56/176 (32%)
		7tm_1	58..334	CDD:278431	89/328 (27%)
Htr1f	NP_032336.1	7tm_4	33..>155	CDD:304433	43/125 (34%)
		7tm_1	41..347	CDD:278431	89/327 (27%)
		Agonist binding. /evidence=ECO:0000250	99..108		1/8 (13%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	120..122		1/1 (100%)
		Agonist binding. /evidence=ECO:0000250	306..310		2/3 (67%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	343..347		2/3 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910